University of Buffalo Clinical and Translational Science Institute - Supplement Schulyer

CTSA UL 1摘要 布法罗翻译联盟（BTC），其中包括布法罗大学（UB）健康科学 学校，我们地区的主要医疗机构，四个重点研究机构和五个有影响力的社区 合作伙伴，已经开始了一项全面的战略计划，为临床和 翻译研究，以回应我们的社会需求。布法罗是纽约州第二大人口城市 约克州有着丰富的文化历史。2018年布法罗代表性不足的少数民族比例（50%） 与美国2050年的预测相似，使布法罗成为美国30年后的缩影。 我国人口中同样比例的人经历着健康差距。我们CTSA中心的愿景是 创新的研究，在整个翻译频谱，以改善我们的社区和国家的健康。 我们将开发、测试和分享新的方法，以吸引难以吸引的人群并减少健康问题。 我们的社会代表着“未来的人口”。在我们的愿景指导下，CTSA 自我们的CTSA于2015年8月首次获得资助以来， 临床和转化研究的增长。此外，在过去的一年里，UB医学院已经进入 一个壮观的新建筑和我们的临床合作伙伴，Kaleida健康，该地区最大的医疗保健系统， 开设了新的Oishei儿童医院，无论是在布法罗尼亚加拉医学院校园，并连接到 临床和转化研究中心完全致力于临床和转化研究，于2009年开业。 2012.该地区医疗保健和研究的快速持续增长导致了 一个新的21世纪世纪学术健康中心，拥有医疗保健、医学教育、临床和翻译 在布法罗中心的一个校园进行研究，创建一个基础，以提高我们的CTSA的影响，甚至 进一步.在启动我们的CTSA的同时，我们通过主办 并将创新实验室作为团队科学工具进行测试，与多个中心合作， 研究障碍，以及我们与CTSA联盟开发的共享工具，包括新的健康 信息学工具。我们的CTSA有五个雄心勃勃但可以实现的目标，包括：1）加速创新 与社区，区域利益相关者和国家联盟合作的团队进行转化研究; 2)培养一支优秀的、多样化的劳动力队伍，以促进发现的翻译; 3）加强对特殊知识的包容性， 整个生命周期的人群和难以参与的人群; 4）简化临床研究过程 注重质量和效率，重点是多中心研究; 5）开发，测试和共享生物医学 信息学工具，以整合来自多个来源的数据，以加快翻译。以我们的愿景为指导， 研究，以改善我们的社区和国家的健康，我们将继续我们的势头，扩大 转化研究，培训我们多样化的员工队伍，简化流程，参与我们的社区，并积极 为国家财团做贡献。 CTSA多样性补充：“了解戒烟应用程序使用的种族差异， 吸烟行为”;斯凯勒C.劳森，PI 这种多样性补充的候选人是非洲裔美国人的背景。完成本补充 将使他能够研究在使用戒烟智能手机应用程序及其 对吸烟行为的影响。此外，他还将接受纵向数据分析研究技能、健康 在临床和转化研究领域的差异，物质使用和专业发展。 该提案与CTSA UL 1奖项的目标有关，如目标2，3，因为研究将 涉及培训来自不同背景的候选人，研究主要集中在边缘化 这是一个经常被描述为难以接触的群体。这些目标将通过分析加以解决 烟草使用与健康的人口评估（PATH）研究，这是一项具有全国代表性的多波研究， 在美国国立卫生研究院（NIH）和美国食品药品监督管理局（FDA）的赞助下进行的一项研究 （FDA）。 为了完成拟议的补充研究，Lawson先生将使用以下CTSA核心：（1 生物统计学，流行病学，研究设计（BERD）研究训练营学习先进的统计 方法，研究设计和假设制定;（2个良好的临床实践研讨会系列，以了解如何 准备IRB提交材料，并更加熟悉保护人类健康的基本原则， 研究参与者。此外，劳森先生将利用以下CLIMB计划研讨会，以实现 拟议的补充研究：（1）CLIMB科学交流成功研讨会系列， 加强演讲技巧，熟悉奖学金申请程序，并为职业生涯做好准备 （2）CLIMB Advanced Writing for Excellence in Research，以学习适当的语法， 培养更好的科学写作技巧。

CTSA UL1 Abstract The Buffalo Translational Consortium (BTC), which includes the University at Buffalo (UB) health sciences schools, the major healthcare institutions in our region, four key research institutes, and five influential community partners, have embarked on a comprehensive strategic plan to build a strong foundation for clinical and translational research in response to our community needs. Buffalo is the second most populous city in New York State and has a rich cultural history. The proportion of underrepresented minorities in Buffalo in 2018 (50%) parallels that projected for the US in 2050, making Buffalo a microcosm of what the US will look like in 30 years. A similar proportion of our population experiences health disparities. The vision for our CTSA hub is to perform innovative research across the translational spectrum to improve the health of our community and the nation. We will develop, test, and share novel approaches to engage difficult-to-engage populations and reduce health disparities in our community, which represents a “population of the future”. Guided by our vision, the CTSA has catalyzed a transformation of our environment since our CTSA was first funded in August 2015 with remarkable growth in clinical and translational research. Further, in just the past year, the UB medical school has moved into a spectacular new building and our clinical partner, Kaleida Health, the largest healthcare system in the region, opened the new Oishei Children’s Hospital, both on the Buffalo Niagara Medical Campus and connected to the Clinical and Translational Research Center devoted entirely to clinical and translational research that opened in 2012. This rapid and continuing trajectory of growth in healthcare and research in the region has resulted in a new 21st century Academic Health Center with healthcare, medical education, and clinical and translational research on one campus in the heart of Buffalo, creating a foundation to enhance the impact of our CTSA even further. While launching our CTSA, we have prioritized participation in the national consortium through hosting and testing Innovation Labs as a team science tool, working with multiple hubs on initiatives to solve translational research barriers, and sharing tools that we have developed with the CTSA consortium, including novel health informatics tools. Our CTSA has five ambitious but achievable aims, including: 1) Accelerate innovative translational research with teams that engage communities, regional stakeholders, and the national consortium; 2) Train an excellent, diverse workforce to advance the translation of discoveries; 3) Enhance inclusion of special populations across the lifespan and difficult-to-engage populations; 4) Streamline clinical research processes focusing on quality and efficiency with emphasis on multisite studies; 5) Develop, test and share biomedical informatics tools to integrate data from multiple sources to speed translation. Guided by our vision to perform research to improve the health of our community and the nation, we will continue our momentum to expand translational research, train our diverse workforce, streamline processes, engage our community, and actively contribute to the national consortium. CTSA Diversity Supplement: “Understanding racial differences in smoking cessation app utilization and smoking behavior”; Schuyler C. Lawson, PI The candidate for this diversity supplement is of African American background. Completion of this supplement will allow him to examine racial differences in the utilization of smoking cessation smartphone apps and their impact on smoking behaviors. Additionally, he will be trained in longitudinal data analysis research skills, health disparities, substance use, and professional development in the areas of clinical and translational research. This proposal relates to the aims of the parent CTSA UL1 award such as Aims 2, 3 in that the research will involve training a candidate from a diverse background and the research is primarily focused on a marginalized population that is often characterized as difficult-to-engage. Those aims will be addressed through the analysis of the Population Assessment of Tobacco Use and Health (PATH) study, a nationally representative multi-wave study created under the auspices of the National Institutes of Health (NIH) and the Food and Drug Administration (FDA). To complete the proposed supplemental research, Mr. Lawson will utilize the following CTSA cores: (1 Biostatistics, Epidemiology, Research Design (BERD) Research Bootcamp to learn advanced statistical methodology, study design, and hypothesis formulation; (2 Good Clinical Practice Workshop Series to learn how to prepare IRB submissions and become more familiar with the fundamental principles of the protection of human research participants. Additionally, Mr. Lawson will utilize the following CLIMB program workshops to achieve the proposed supplemental research: (1) CLIMB Scientific Communication for Success Workshop series to bolster presentation skills, familiarize himself with the fellowship application process, and prepare him for careers in academia; (2) CLIMB Advanced Writing for Excellence in Research to learn proper grantsmanship, and develop finer scientific writing skills.