Alcohol Center Of Research -- Nebraska (ACORN)

内布拉斯加州酒精研究中心(ACORN)的目标是扩大现有的优势和专业知识 在内布拉斯加州，通过创建一个专注于酒精的中心，在酒精研究领域开拓新的利基市场 曝光体。酒精研究一直是内布拉斯加州的一个主要重点领域(在奥马哈VA医疗 研究服务中心和内布拉斯加大学医学中心)已有50多年的历史。结果, 对酒精研究和酒精性肝病的治疗做出了许多贡献 制造。研究酒精对痕量金属代谢、肺部生物学和生理学的影响， 酒精性脂肪肝的机制、乙醛加合物在酒精性细胞损伤中的作用、肝脏蛋白转运 而信号转导事件和免疫机制在酒精性肝病中的作用已有一些 调查的关键领域。我们的目标是向人类解释曝光中的因素，如年龄， 在有无酒精的情况下，营养状况、吸烟和接触病原体相互作用。 行政管理。我们知道，特定外部环境的一个主要组成部分是生活方式因素 饮酒。因此，在曝光组的综合图式下，酒精代表一种 应与其他内部和外部因素一起考虑的环境暴露 了解疾病进展的原因和本质。我们应用程序的总体假设是 下面：在曝光组的背景下考察酒精将使我们了解它的作用 更全面地研究酒精引起的人类疾病的病因学和随后的表现 病理生理学。该中心的酒精暴露主题在酒精中心中是独一无二的，并具有 具有高度翻译性的潜力。我们的调查人员代表了一支出色的跨学科团队 将由一个行政核心、一个生物学家核心和一个试点项目核心支持的调查人员。 橡子调查人员将可以进入UNMC、内布拉斯加州医疗中心和 内布拉斯加州大学林肯分校。我们包括来自5个系和3个学院的教职员工。我们建议的具体方案 ACORN的目标是：1)促进跨学科研究并确定因素，以便我们能够 在人类中，年龄、营养状况、吸烟和接触病原体是如何相互作用的 或者没有饮酒。2)创建Biosecimen核心，协助中心调查人员晋升 以及开发动物和人类组织和细胞的翻译模型。3)增强协作性 橡子环境，并通过培训、研讨会和试点赠款提供资金机会。工作 在我们的4个研究项目上，有行政核心和生物学家核心的参与，我们将允许 来实现我们的目标。总体而言，这一新的P50将利用过去研究工作的专业知识来 考察酒精，在各种外部和内部环境因素的设置下如何影响疾病 并帮助我们塑造未来的动物和人类研究。

The goal of the Alcohol Center of Research-Nebraska (ACORN) is to expand existing strengths and expertise in Nebraska to develop a novel niche in alcohol research, by creating a Center focused on the Alcohol Exposome. Alcohol research has been a major area of emphasis in Nebraska (at the Omaha VA Medical Center Research Service and at the University of Nebraska Medical Center) for over 5 decades. As a result, many contributions to the field of alcohol research and the treatment of alcoholic liver disease have been made. Studies examining the effects of alcohol on trace metal metabolism, lung biology and physiology, mechanisms of alcoholic fatty liver, role of aldehyde adducts in alcoholic cell injury, hepatic protein trafficking and signal transduction events and the role of immune mechanisms in alcoholic liver disease have been some of the key areas of investigation. Our goal is to translate to humans how factors in the exposome such as age, nutritional status, cigarette smoking, and exposure to pathogens interact in the presence or absence of alcohol administration. We know that a major component of the specific external environment is the lifestyle factor of alcohol consumption. Thus, under the comprehensive schema of the exposome, alcohol represents an environmental exposure that should be considered in context with other internal and external factors to understand causes and nature of disease progression. The overall hypothesis of our application is the following: the examination of alcohol in the context of the exposome will allow us to understand its role more fully in the etiology of disease and the subsequent manifestations of alcohol-induced human pathophysiology. The alcohol-exposome theme of the center is unique among alcohol centers and has the potential to be highly translational. Our investigators represent an outstanding team of interdisciplinary investigators that will be supported by an Administrative Core, a Biospecimen Core, and a Pilot Projects Core. ACORN investigators will have access to state-of-the art facilities at UNMC, Nebraska Medical Center and University of Nebraska-Lincoln. We include faculty from 5 departments and 3 colleges. Our proposed Specific Aims for the ACORN are to: 1) Facilitate interdisciplinary research and identify factors so that we can translate in humans how age, nutritional status, cigarette smoking, and exposure to pathogens interact in the presence or absence of alcohol administration. 2) Create a Biospecimen Core to aid Center investigators in promotion and development of translational animal and human tissue and cell models. 3) Enhance the collaborative ACORN environment and provide opportunities for funding through training, symposia, and pilot grants. Work on our 4 research projects, with participation of the Administration Core and the Biospecimen Core will allow us to realize our goals. Overall, this new P50 will utilize the expertise and knowledge of past research efforts to examine how alcohol, in the setting of various external and internal environmental factors will influence disease in a variety of organs and help us shape our future animal and human studies.