Training Grant in Gastroenterology

项目总结/摘要 此申请要求额外五年的加州大学圣地亚哥分校（UCSD）培训 授予胃肠病学继续履行其准备前和博士后研究员的职业目标 作为学术界的独立调查员，进行尖端的基础和/或翻译 胃肠道（GI）疾病相关研究。拟议的培训基于两项原则：㈠ 基础研究推动消化系统疾病诊断和治疗的进步 发现和及时翻译到床边;（ii）大数据（RNA seq，“组学”）提供了一个 大量的数据使这种从模式生物研究到患者的转化成为可能， 计算机工具、系统生物学和生物统计学方面的培训。基于这些原则，UCSD GI T32计划设计了一个全面的，但个性化的培训课程，以（a）实现 在先进系统和方法方面的卓越研究，（B）提供基础知识，跟上时代的步伐 与进步和发展转化的见解，（c）通过一个促进合作的社区， 充满活力的跨学科培训。通过这些活动，GI T32计划旨在加快 发现和推进消化系统疾病的精确管理，这是直接 符合NIDDK减轻这些疾病负担的目标。本培训计划利用 继续扩大UCSD医学院及其合作机构的生物医学研究 确定具有地理信息相关研究专业知识的教师导师，富有成效的研究计划，原则性 研究行为和优秀的培训历史，从医学系，家庭医学， 细胞与分子医学、儿科学、病理学、药理学、外科学和药学 以理工科为重培训计划使受训人员和教师接触到系统的多样性， 方法和技术，用于研究复杂的生物学和翻译 一系列胃肠道疾病的各个方面，包括炎症性肠病、功能性胃肠道疾病和 运动，肠道感染性疾病，肠道微生物组，胰腺和肝胆疾病，营养和 肥胖症和消化道恶性肿瘤。在过去的十年里，该专业的博士前和博士后学员 计划已进入生产性研究事业的成功率分别为100%和~ 90%， 研究科学家和教师。加州大学圣地亚哥分校GI T32项目执行委员会，由该项目组成 主任、副主任和一个内部咨询委员会，负责挑选和评估受训人员， 教师以及监测程序内的进展。UCSD GI T32外部咨询委员会 审查计划统计数据和指标，以确定培训活动的优势和劣势， 学员和教员。通过这些活动和UCSD医学院的支持，该计划将 继续作为一个在加州大学圣地亚哥分校地理信息为重点的基础和转化研究和培训的纽带。

PROJECT SUMMARY/ABSTRACT This application requests five additional years for the University of California, San Diego (UCSD) Training Grant in Gastroenterology to continue to fulfill its goal of preparing pre- and post-doctoral fellows for careers as independent investigators in academia, conducting cutting-edge basic and/or translational gastrointestinal (GI) disease-related research. The proposed training is based on two principles: (i) Advancements in diagnosis and treatment of digestive disorders are propelled by basic research discoveries and their timely translation to the bed side; (ii) Big data (RNA seq, 'omics') has provided a wealth of data to enable such translation from model organism research to patients and requires rigorous training in computational tools, systems biology and biostatistics. Based on these principles, the UCSD GI T32 program has designed a comprehensive, and yet individualized training curriculum to (a) achieve research excellence in advanced systems and approaches, (b) provide foundation knowledge, keep pace with advancements and develop translational insights, and (c) foster a collaborative community through a vibrant interdisciplinary training. With these activities, the GI T32 program aims to accelerate the pace of discovery and to advance the delivery of precision management in digestive disorders, which is directly aligned to NIDDK's goals of lessening the burden of these ailments. This Training Program leverages the continuing expansion of biomedical research at UCSD School of Medicine and its collaborating institutions to identify faculty mentors with GI-relevant research expertise, productive research programs, principled research conduct and outstanding training history from the Departments of Medicine, Family Medicine, Cellular & Molecular Medicine, Pediatrics, Pathology, Pharmacology, Surgery, and Pharmaceutical Sciences. The Training Program exposes the trainees as well as the faculty to the diversity of systems, approaches and technologies that are employed to investigate the complex biology and translational aspects of a range of GI disorders, including inflammatory bowel disease, functional GI disorders and motility, infectious diseases of the gut, gut microbiome, pancreatic and hepatobiliary disorders, nutrition and obesity, and malignancies of the digestive tract. In the past decade, pre-doc and post-doc trainees of this program have entered productive research careers with a success rate of 100% and ~90%, respectively, as research scientists and faculty. The UCSD GI T32 program Executive Committee, consisting of the Program Director, Associate Director, and an Internal Advisory Committee that selects and evaluates trainees and faculty as well as monitors progress within the Program. The UCSD GI T32 External Advisory Committee reviews program statistics and metrics to identify the strengths and weaknesses of training activities, trainees and faculty. With these activities and support from the UCSD School of Medicine, this program will continue to function as a nexus for GI-focused basic and translational research and training at UCSD.