Activity-Dependent Mechanisms of Memory Consolidation

项目总结 视觉是一种主动的感觉，眼球运动有力地塑造了视觉的获得 关于世界的信息。这个项目调查运动学习是如何调节神经的。 控制眼球运动的电路，以保持眼球运动的准确性 时间尺度很长。这项研究的具体重点是了解眼球运动学习是如何， 即通过经验提高眼动的准确性，这是从 从短期存储到长期存储。这种巩固过程不仅发生在像这样的运动技能上 眼球运动，但这是学习和记忆系统的一般特征。一些回忆， 包括动眼记忆，在最初获得运动记忆后的一段时间内发生变化 记忆，以一种使较老的、巩固的记忆独立于大脑区域的方式 对较新的记忆至关重要。这一过程被称为系统整合，被认为依赖于 关于最初对记忆至关重要的脑区神经元的活动，假设是 这种活动会导致支持记忆长期存储的大脑区域(S)发生变化。 这项拟议的研究描述了大脑之间传递的神经信号的性质 在获取后的不同时间支持内存的区域，以及操作的规则 这些神经信号实现了记忆从一个大脑区域到另一个区域的稳定转移。

PROJECT SUMMARY Vision is an active sense, with eye movements powerfully shaping the acquisition of visual information about the world. This project investigates how motor learning adjusts the neural circuitry controlling eye movements, to maintain the accuracy of eye movements over short and long time scales. The specific focus of the research is to understand how oculomotor learning, i.e., improvement of the accuracy of eye movements through experience, is transferred from short-term to long-term storage. This consolidation process occurs, not only for motor skills like eye movements, but is a general feature of learning and memory systems. Some memories, including oculomotor memories, are transformed during the time after the initial acquisition of the memory, in a way that renders older, consolidated memories independent of brain areas that are critical for newer memories. This process, known as systems consolidation, is thought to depend on activity of neurons in the brain area initially critical for the memory, and the hypothesis is that this activity induces changes in the brain area(s) supporting long-term storage of the memory. The proposed research characterizes the nature of the neural signals transmitted between brain areas supporting memory at different times after their acquisition, and the rules that operate on those neural signals to implement stable transfer of a memory from one brain area to another.