FASEB SRC: The Folate, Vitamin B12, and One-Carbon Metabolism Conference

两年一度的题为“叶酸、维生素B12和一碳代谢”的会议将在 2022年8月14日至19日，北卡罗来纳州阿什维尔的万丽酒店。这个会议是澳大利亚联邦的一部分 美国实验生物学学会夏季研究会议(SRC)系列 自1986年成立以来，每两年召开一次会议。会议的理念是将基本的 研究人员、临床医生和公共卫生专家介绍和讨论与B组相关的最新进展 维生素和一碳新陈代谢。参加会议的通常是世界上最著名的专家 来自世界各地的外地研究人员以及完成博士和博士后研究的年轻研究人员。 会议的具体目的是：1)召集维生素B领域的世界专家和实习生 和一碳代谢，介绍和讨论最新的尖端研究，强调未发表的 数据；2)为新参加会议的受训者和调查人员提供机会介绍他们的工作，获得 来自该领域现有调查人员的反馈，并发展合作和专业联系； 以及3)通过为受邀演讲者提供旅费和奖励旅费来促进出席会议 颁发给毕业生和博士后实习生的优秀口头和海报演示文稿。资金被分配 增加任职人数不足的少数群体的出席率，并加强他们的积极参与。科学 2022年会议的亮点包括：1)1)碳营养、其新陈代谢与癌症；2) 微生物组在1-碳代谢中的作用，3)1-碳代谢的基本方面及其临床 含义，4)1-碳营养及其代谢在慢性疾病中的作用，5)遗传性疾病 1-碳代谢，6)1-碳营养素的膳食推荐摄入量(DRI)所需的更新 (研讨会形式)，7)过量摄入叶酸的潜在不良影响：一个持续的争议，8) 1-碳代谢与母子健康的关系，以及9)特质 癌细胞对蛋氨酸的依赖性。 具体目标将通过10个会议实现，其中包括受邀演讲者的口头陈述 (30分钟演讲)和从提交给会议的精选摘要(15分钟演讲；扩大 为学员提供口头陈述的机会)，两次海报会议(每次2小时)，以及两次“见面- 专家/职业发展会议，受训人员和年轻调查人员将在这些会议上会见高级调查人员 讨论研究和专业发展。还将有大量的机会进行非正式的 参与者在用餐、休息、海报会议和户外娱乐活动中的互动。 这些互动将催化新的研究方向和合作，促进专业 发展青年科研人员，振兴该领域的未来。

The biennial conference entitled “Folate, Vitamin B12 and One-Carbon Metabolism” will be held at the Renaissance Hotel in Asheville, NC, August 14-19, 2022. This conference, which is part of the Federation of American Societies for Experimental Biology (FASEB) Summer Research Conference (SRC) series has been convened every two years since its inception in 1986. The philosophy of the conference is to bring together basic researchers, clinicians, and public health experts to present and discuss the latest developments related to B vitamins and one-carbon metabolism. The conference is typically attended by the most prominent experts in the field from around the world, as well as young investigators completing their doctoral and postdoctoral studies. The Specific Aims of the conference are to: 1) convene world experts and trainees in the area of B vitamins and one-carbon metabolism to present and discuss the latest, cutting edge research, emphasizing unpublished data; 2) provide opportunities for trainees and investigators new to this meeting to present their work, receive feedback from established investigators in the field, and develop collaborations and professional connections; and 3) promote attendance at the conference by providing travel funding for invited speakers and awarding travel prizes to graduate and postdoctoral trainees for outstanding oral and poster presentations. Funds are allocated to enhance attendance by under-represented minorities and to enhance their active participation. Scientific highlights of the 2022 meeting include sessions on: 1) 1-carbon nutrients, their metabolism, and cancer, 2) the roles of the microbiome in 1-carbon metabolism, 3) basic aspects of one-carbon metabolism and their clinical implications, 4) the role of 1-carbon nutrients and their metabolism in chronic disease, 5) hereditary disorders of 1-carbon metabolism, 6) the updates required for the Dietary Recommended Intakes (DRIs) of 1-carbon nutrients (a workshop format), 7) potential adverse effects of excess intake of folic acid: an ongoing controversy, 8) the relationship between 1-carbon metabolism and maternal and offspring health, and 9) the idiosyncratic dependence of methionine by cancer cells. The specific aims will be achieved through 10 sessions consisting of oral presentations from invited speakers (30 minute talks) and from selected abstracts submitted to the conference (15 minute talks; expanding opportunities for trainees to give oral presentations), two poster sessions (2 hours each), and two ‘meet-the- expert/career development’ sessions in which trainees and young investigators will meet with senior investigators to discuss research and professional development. There also will be ample opportunities for informal interactions among the participants during meals, breaks, poster sessions, and outdoor recreational activities. These interactions will catalyze new research directions and collaborations, promote the professional development of young investigators, and invigorate the future of the field.