FASEB SRC: The Gastrointestinal Tract XIX Conference: Making and Breaking a Gut

项目摘要/摘要 本申请请求部分支持FASE B名为“胃肠”的科学研究会议 《第19道：制造和打破肠子》定于2022年8月7日至12日在科罗拉多州蒸汽船斯普林斯举行。 会议将召集不同的发言者群体，其中包括许多妇女、代表性不足的少数群体。 和年轻的研究人员，讨论胃肠道的生物学和它在环境中的失调 疾病的威胁。主旨演讲外加八个讲座将讨论胃肠道干细胞的动态平衡。 和可塑性对伤害/疾病的反应，营养和新陈代谢，使用胃肠道有机化合物的新方法， 微生物区系-肠道-脑轴，上皮生理学，微生物动态平衡和疾病发病机制，粘膜 炎症和IBD，还有癌症。将预留充足的时间供与会者讨论，并 将对未公布数据的提交进行优先排序。还将有两个海报会议以及几个 针对早期职业调查员和实习生的职业发展活动，以及晋升机会 这些代表着该领域未来的个人的知名度。我们已经组装了一款创新的 GI相关研究领域内具有不同专业知识的领导者承诺参与的计划。 总体而言，在一个私密和隐蔽的环境中，鼓励科学家之间的非正式互动 ，我们为思想交流和科学综合提供了一种创新的方法，这将推动 胃肠道疾病研究领域的前沿。这次会议将产生很大的影响，因为该计划涉及基础科学 这一发现对胃肠道健康和疾病具有临床意义。因此，预计这次会议将提供 不仅对基础胃肠生理学、神经生物学、发育生物学和 微生物学，但也如何治疗，并最终治愈，各种各样的消化疾病状态。

Project summary/abstract This application requests partial support for a FASEB Scientific Research Conference entitled “Gastrointestinal Tract XIX: Making and Breaking the Gut” that is scheduled for August 7-12, 2022 in Steamboat Springs, CO. The meeting will convene a diverse group of speakers, including many women, underrepresented minorities and young investigators, to discuss the biology of the gastrointestinal tract and its dysregulation in the setting of disease. A keynote address plus eight lecture sessions will address gastrointestinal stem cell homeostasis and plasticity in response to injury/disease, nutrition and metabolism, novel approaches using GI organoids, the microbiota-gut-brain axis, epithelial physiology, microbial homeostasis and disease pathogenesis, mucosal inflammation and IBD, and cancer. Ample time will be set aside for discussions amongst participants, and the presentation of unpublished data will be prioritized. There will also be two poster sessions as well as several career development activities for early career investigators and trainees, as well as opportunities to promote the visibility of these individuals who represent the future of the field. We have assembled an innovative program with committed participation from leaders with diverse expertise within GI-related research fields. Overall, in an intimate and secluded setting that encourages informal interactions between scientists at all levels, we provide an innovative approach to the exchange of ideas and synthesis of science that will move the field of GI research forward. The conference will have high impact as the program spans basic science discovery to clinical significance for GI health and disease. It is therefore expected that the meeting will provide new insights not only into basic gastrointestinal physiology, neurobiology, developmental biology and microbiology, but also how to treat, and ultimately cure, a wide variety of digestive disease states.