ISMRM workshop on MRI of Neuromodulation

项目概要/摘要： 近年来，神经调节技术如经颅直流电刺激（tDCS）， 经颅磁刺激（TMS）和脑深部电刺激（DBS），以及使用 光学和超声波调制，已成为研究复杂的神经回路如何 在大脑中相互作用，操纵人类认知和治疗大脑疾病。磁共振成像 (MRI)现在可以与这些神经调节技术同时或前后进行， 可视化它们对人类大脑的影响，了解神经生理学机制，并提高他们的 功效该主题与MRI引导治疗的ISMRM主题和日益增长的兴趣高度相关， 植入物的MRI。它也符合NIH脑倡议的目标和公众对脑机的兴趣 比如Elon Musk的Neuralink。拟议的ISMRM研讨会“MRI在神经调节： 目标参与，神经机制和生物标志物的发展”将汇集一个不同的群体 科学家和临床医生以及对开发和应用先进技术感兴趣的行业合作伙伴 MRI技术用于可视化、理解和量化神经调节对人脑的影响。这 研讨会将是ISMRM历史上首次以MRI在神经调节中的主题为主题的研讨会。建议2.5 为期两天的研讨会将于2022年10月17日至19日在马里兰州贝塞斯达的NIH校园举行。该计划将 为高级研究人员和初级科学家设计。组委会还将强调， 参加ISMRM的受训成员，代表性不足的团体和从事国际研究 社区，并将与行业合作伙伴合作，以确保资金，为学员提供旅行支持。的 会议将包括邀请和提供口头报告，以及简短的权力间距海报会议。的 研讨会的时间表将结合介绍与充分的讨论时间，涵盖各种进展， 用于神经调节的MRI技术（电磁场标测、功能连接、动脉自旋标记 灌注和通透性、温度和声辐射力成像等）、临床前动物模型 神经调节的细胞水平机制，以及与神经调节MRI相关的安全性问题 装置. MRI在神经调节和生物标志物开发中的现有和新兴临床应用将 在学术界和行业合作伙伴之间进行讨论。

Project Summary/Abstract: During recent years, neuromodulation techniques such as transcranial direct current stimulation (tDCS), transcranial magnetic stimulation (TMS) and deep brain stimulation (DBS), as well as alternative methods using optical and ultrasonic modulations, have become an important means to study how complex neural circuits interact in the brain, to manipulate human cognition and to treat brain disorders. Magnetic resonance imaging (MRI) can now be performed either concurrently with or pre and post these neuromodulation techniques to visualize their effects on the human brain, to understand the neurophysiological mechanism and to improve their efficacy. This topic is highly relevant to the theme and growing interests of ISMRM for MRI guided therapy and MRI with implants. It also aligns with the goals of the NIH BRAIN Initiative and public interest in brain-computer interfaces such as Elon Musk’s Neuralink. The proposed ISMRM workshop on “MRI in Neuromodulation: Target Engagement, Neural Mechanism, and Biomarker Development” will bring together a diverse group of scientists and clinicians as well as industry partners who are interested in developing and applying advanced MRI techniques to visualize, understand and quantify neuromodulation effects on the human brain. This workshop will be the first of its kind on the topic of MRI in neuromodulation in ISMRM history. The proposed 2.5 days workshop will take place Oct 17-19, 2022 on the NIH campus in Bethesda MD. The program will be designed for both senior investigators and junior scientists. The organizing committee will also emphasize attendance by trainee members of ISMRM, underrepresented groups and engage the international research community, and will work with industry partners to secure funding to provide travel support for trainees. The meeting will include invited and proffered oral presentations as well as short power-pitch poster sessions. The workshop’s schedule will integrate presentations with ample discussion periods covering advances in various MRI techniques for neuromodulation (electromagnetic field mapping, functional connectivity, arterial spin labeled perfusion and permeability, temperature and acoustic radiation force imaging etc), pre-clinical animal models and cellular-level mechanisms of neuromodulation, and safety issues related to MRI with neuromodulation devices. Existing and emerging clinical applications for MRI in neuromodulation and biomarker development will be discussed between academic and industry partners.