University of Wisconsin Prostate SPORE

项目总结 威斯康星大学(UW)前列腺癌孢子是一个高度合作的研究提案，它将 基础科学家与前列腺癌临床医生共同推进前列腺癌患者的治疗策略。这个 这个孢子的主要目标是：1)增加多学科的翻译研究，并开发下一个 一代前列腺癌研究人员，2)开发共同资源以促进进展，3)翻译 有希望的新方法进入患者，以及4)改善患者的总体生存和生活质量 前列腺癌。围绕这种孢子的一个横切主题是了解肿瘤的耐药性 晚期前列腺癌和利用这一知识来改善患者的预后。威斯康星州的前列腺癌 孢子有三个主要的研究项目：1)转移级联的肿瘤微环境启动者 高危前列腺癌，2)作为免疫调节疗法的雄激素剥夺联合 前列腺癌的靶向免疫治疗，以及3)通过选择性治疗扩大临床受益 MCRPC中的耐药病变。孢子将通过三个核心(行政、集成)支持这项研究 病理学、放射学、生物统计学和生物信息学)。职业提升计划和 发展研究计划将吸引新的和现有的研究人员以及更多的翻译目标 在一个丰富的多学科环境中。完成后，UW前列腺癌孢子的研究将 促进我们对前列腺癌的治疗和理解，无疑对患者产生有益影响 这种病。

PROJECT SUMMARY The University of Wisconsin (UW) Prostate Cancer SPORE is a highly collaborative research proposal that links basic scientists with prostate cancer clinicians to advance treatment strategies for prostate cancer patients. The broad objectives of this SPORE are to: 1) Increase multidisciplinary translational research and develop the next generation of prostate cancer researchers, 2) Develop common resources to promote advances, 3) Translate promising new approaches into patients, and 4) Improve overall survival and quality of life for patients with prostate cancer. A crosscutting theme that encompasses this SPORE is understanding tumor resistance in advanced prostate cancer and exploiting this knowledge to improve patient outcomes. The UW Prostate Cancer SPORE has three primary research projects: 1) Tumor Microenvironment Initiators of the Metastatic Cascade in High-Risk Prostate Cancer, 2) Androgen Deprivation as an Immune Modulating Therapy in Combination with Targeted Immunotherapy of Prostate Cancer, and 3) Extending Clinical Benefit by Selective Treatment of Resistant Lesions in mCRPC. The SPORE will support this research with three Cores (Administrative, Integrated Pathology Radiology, and Biostatistics and Bioinformatics). The Career Enhancement Program and Developmental Research Program will engage new and established investigators and further translational goals in a rich multidisciplinary environment. When completed, the research of the UW Prostate Cancer SPORE will advance our treatments and understanding of prostate cancer and undoubtedly beneficially impact patients with this disease.