Administrative Core

摘要行政核心 多中心骨关节炎（MOST）研究的使命是实施、促进和促进高影响力 研究骨关节炎（OA）的病因和预防及其疼痛和功能丧失的后果。 在拟议的MOST第四周期（MOST 4）期间，我们计划通过收购实现这一目标， 管理、分析和共享有关OA、风险因素和疾病功能后果的数据。的 MOST 4行政核心的主要目标是确保各项程序到位并发挥作用， 支持完成这一使命。行政核心将管理财务， 相互作用：1）在研究单元（核心（临床数据收集和管理，分析， 成像）和项目）; 2）与外部研究人员; 3）参与MOST研究的机构之间 包括波士顿大学、亚拉巴马大学伯明翰分校、加州大学弗朗西斯科分校、 爱荷华州大学;资助机构（NIA）;阅读中心;和专业实验室。 核心将在核心共同领导人大卫费尔森博士和Tuhina Neogi博士的领导下，由一位 执行委员会由其他核心的领导人组成。MOST 4调查员的整个团队包括 资深经验丰富的NIH资助的教师和初级教师的混合建立自己的职业生涯，重点是研究 OA，疼痛和残疾。MOST研究的第一个周期（MOST 1）于2001年获得资助， 隶属于这个队列有着悠久的合作历史，发表了180多篇论文，报告 与OA流行病学和风险因素、疼痛、功能和其他结局相关的重要发现。中 这项研究的独特之处在于其调查人员和研究的多学科性。一系列主题 已经进行了研究，包括膝关节的MRI表现、疼痛敏感性、地面生物力学数据等 反作用力，肌肉功能的测量，晶体沉积的研究，身体活动的评估， 还有其他的目前关于社会变革管理计划第四周期的建议是对这一建议的扩展。 多学科聚焦。行政核心的目标是提供领导，以成功地管理 总体研究执行;计划、指导和整合所有社会变革管理计划研究活动;提供透明的 跨项目和核心的沟通;并促进跨项目协作。我们将实现这些目标 通过为以下具体目标提供领导和行政监督：科学和 业务管理，包括单一的机构审查委员会程序;财务管理;研究 产出管理和传播;试点赠款方案;社区咨询委员会参与; 沟通和外部协作。通过这些活动，行政核心将确保 在调查员小组的有力和协作领导下，MOST 4的成功运作。

ABSTRACT Administrative Core The mission of the Multicenter Osteoarthritis (MOST) study is to conduct, facilitate, and promote high impact research on the etiology and prevention of osteoarthritis (OA) and its consequences of pain and loss of function. During the proposed 4th cycle of MOST (MOST4), we plan to accomplish this goal through the acquisition, management, analysis and sharing of data on OA, risk factors and functional consequences of disease. The primary goal of the MOST4 Administrative Core is to ensure that processes are in place and functioning to support the accomplishment of this mission. The Administrative Core will manage finances, and the following interactions: 1) internally among the study units (the Cores (Clinical Data Collection and Management, Analysis, Imaging) and Projects); 2) with external researchers; 3) between institutions involved in the MOST study including Boston University; University of Alabama, Birmingham; University of California, San Francisco; University of Iowa; the funding agency (NIA); reading centers; and specialized laboratories.The Administrative Core will be under the leadership of Core co-Leaders Drs. David Felson and Tuhina Neogi, supported by an Executive Committee consisting of the other Cores' leaders. The overall team of MOST4 investigators include a mix of senior experienced NIH-funded faculty and junior faculty establishing their careers with a focus on studies of OA, pain and disability. The first cycle of the MOST study (MOST1) was funded in 2001, and investigators affiliated with this cohort have a long history of collaboration, having published over 180 papers reporting important findings related to OA epidemiology and risk factors, pain, function, and other outcomes. Among the unique features of the study has been the multidisciplinarity of its investigators and research. A range of topics have been studied, including MRI findings in the knee, pain sensitization, biomechanical data such as the ground reaction force, measurement of muscle function, studies of crystal deposition, assessment of physical activity, among others. The current proposal for the 4th cycle of MOST (MOST4) represents an expansion of this multidisciplinary focus. The goals of the Administrative Core are to provide leadership to successfully manage the overall study's execution; plan, direct and integrate all MOST study activities; provide transparent communication across projects and cores; and foster cross-project collaboration. We will accomplish these goals through providing leadership and administrative oversight for the following Specific Aims: Scientific & Operational Management, including single Institutional Review Board processes; Financial Management; Study Output Management & Dissemination; Pilot Grant Program; Community Advisory Board Engagement; Communications & External Collaboration. Through these activities, the Administrative Core will ensure the successful operations of MOST4 under the strong and collaborative leadership of the investigator team.