Training Grant in Clinical Pharmacology

摘要 该提案是对NIH赞助的临床药理学T32的持续资助的请求 马约诊所的研究员培训计划。这个长期运行的计划的基础是强大的 在最先进的生物医学研究的培训，适用于人与药物的相互作用，即，临床 药理学。马约临床药理学培训经验包括一门课程， 受训者迅速发展的科学，基础临床药理学。然而，除了强大的 课程，包括药代动力学，药物代谢和药物基因组学，在心脏 该计划是在一个支持性的指导下杰出的个人研究经验 环境临床药理学是分子药理学、多种药理学 “组学”，以及越来越多的令人兴奋的分析技术，如人工智能和机器 该中心已接受并应用于药物机制研究的学习技术， 药物反应这些分析技术与马约诊所项目所具有的领导力的结合 多年来在临床药理学中应用“多组学”所证明的这一点将有助于推动我们 更接近真正的“个体化”和“合理”药物治疗的双重目标。我们建议利用 生物医学和计算机科学领域的巨大进步所代表的机遇 通过加入最新的基于实验室的科学来培训下一代临床药理学家 药理学与现代计算技术，以提高机制的理解 和药物反应的可预测性。综合性、高度整合的学术医疗中心， 马约诊所是解决这一挑战理想场所。马约诊所有一个历史， 并整合了杰出的基础和临床医学研究以及持续贡献的传统 临床药理学的学科和数十年的经验，招聘和培训医生 临床药理学的科学家和实验室转化科学家。在下一个供资周期， 马约临床药理学奖学金培训计划将继续强调强大的实验室- 在支持性的指导环境中进行基于研究的培训，并与不断发展的课程相结合 以及系统地接触生物医学和计算科学的进步--所有这些都是为了实现这一目标 准备每个研究员参加该计划，成为未来的领导者，在临床药理学， 学术界、工业界和监管机构。

ABSTRACT This proposal is a request for continued funding of the NIH-sponsored Clinical Pharmacology T32 Fellowship Training Program at the Mayo Clinic. The foundation for this long-running program is strong training in state-of-the-art biomedical research as applied to human-drug interactions, i.e., Clinical Pharmacology. The Mayo Clinical Pharmacology training experience includes a curriculum that exposes Trainees to the rapidly evolving science that underlies Clinical Pharmacology. However, beyond a strong curriculum that includes pharmacokinetics, drug metabolism and pharmacogenomics, at the heart of the Program are outstanding individual research experiences within a supportive mentoring environment. Clinical Pharmacology lies at the confluence of molecular pharmacology, multiple “omics” and, increasingly, exciting analytical techniques such as Artificial Intelligence and Machine Learning—techniques that this center has embraced and applied to studies of drug mechanisms and drug response. The union of these analytical techniques with the leadership that the Mayo Clinic Program has demonstrated over the years in the application of “multiple omics” to Clinical Pharmacology will help move us closer to the twin goals of truly “individualized” and “rational” drug therapy. We propose to take advantage of the opportunity represented by the dramatic advances occurring in biomedical and computational science to train the next generation of Clinical Pharmacologists by joining the latest laboratory-based pharmacologic science with modern computational techniques to enhance mechanistic understanding and the predictability of drug response. Comprehensive, highly integrated academic medical centers like the Mayo Clinic are ideally positioned to address this challenge. The Mayo Clinic has a history of performing and integrating outstanding basic and clinical medical research as well as a tradition of continuing contributions to the discipline of Clinical Pharmacology and decades of experience in recruiting and training both physician scientists and laboratory-based translational scientists in Clinical Pharmacology. During the next funding cycle, the Mayo Clinical Pharmacology Fellowship Training Program will continue to emphasize strong laboratory- based research training in a supportive mentored environment joined with a continually evolving curriculum and systematic exposure to advances in biomedical and computational science—all directed toward the goal of preparing each Fellow enrolled in the Program to become a future leader in Clinical Pharmacology in academia, in industry and in regulatory agencies.