Much-efficient and cost-effective manufacturing of antibody biotherapeutics employing integrated negative chromatography technology

目前部署在生物加工行业的平台抗体纯化过程变得效率较低，成本效益较低，无法与高滴度上游技术相匹配。基于之前使用模型抗体进行的可行性研究，该项目的主要目的和目标是研究使用真实工业原料的负层析技术，以显著提高上述整个过程的效率问题。下游生物制药加工行业的市场规模约为30-50亿美元，这是一个可以发挥作用的全球市场。该项目的成功结果将为行业带来巨大的潜在成本效益。

The current platform antibody purification process deployed in the bioprocesing industry becomes less efficient and less cost-effective to match with high titre upstream technologies. Based on previous feasibility studies using model antibodies, the key aim and objective of this project is to investigate negative chromatography based technologies using real industrial feedstocks to dramatically improve the overall process efficiency issue as described above. The market size in the downstream biopharmaceutical processing sector is ca $3 - 5 billions and it is a global market to play. The successful outcomes of this project will bring enormous potential cost benefits to the industry.