DIETARY ENERGY RESTRICTION AND METABOLIC AGING IN WOMEN

饮食限制（DR）是唯一已知的延长寿命的干预措施 并降低动物物种的衰老速度。 的问题 DR可能在人类中产生类似的益处仍然未知， 本研究的主题。 许多人强制实行自愿的饮食 对自己的能量限制，以及心理测量的程度 这种“饮食限制”的研究将成为人类DR研究的基础。 特别是，我们将研究DR对年龄敏感性 与体型无关的代谢参数， 将决定DR是否对女性的健康益处超过任何 由于减肥而获得的好处。 待检验的主要假设是：1）心理测量 饮食限制与总能量的显著减少有关 支出和能量摄入的中年妇女，如前所述 在年轻妇女中，与体力活动和身体水平无关 组合物; 2）饮食限制，结合消费 充足的蛋白质、维生素和矿物质摄入量， 身体活动和身体组成的变化， 在一系列选定的年龄敏感的代谢和生理变量中， 这表明中年女性的生物衰老率降低。 的 受试者将是66名年龄为55-62岁的健康绝经后妇女， 一半被归类为长期限制进食者，另一半被归类为长期 无节制的食客 将对主体进行组匹配 组成、体力活动水平、祖先寿命和其他 影响发病率和死亡率的因素 在一整天的研究中， 将测定通常的营养摄入量、自由生活总量 能量消耗、静止代谢率、身体组成（身体脂肪， 瘦体重、总骨矿物质和脂肪分布）、免疫功能 (in体内迟发型超敏反应，体外T细胞有丝分裂原刺激 的淋巴细胞，细胞因子和前列腺素E2的生产， 淋巴细胞），胰岛素抵抗，循环胰岛素样生长因子 1、甲状腺状态、血脂谱（总胆固醇、HDL、LDL、VLDL 和甘油三酯）和心肺功能（最大氧 消耗量、血压、用力肺活量和用力呼气 1秒内的体积）。 将评估饮食限制的效果 通过使用标准统计学方法比较两组的结果， 技术. 我们预计这次调查的结果 关于DR在维护 成年人的长期健康。

Dietary restriction (DR) is the only intervention known to prolong lifespan and reduce the rate, of aging in animal species. The question of whether DR may give similar benefits in humans remains unknown and will be the subject of this proposed study. Many humans impose voluntary dietary energy restriction on themselves, and psychometric measures of the extent of this "dietary restraint" will be the basis of a study of DR in humans. In particular, we will be investigating the effects of DR on age-sensitive metabolic parameters that are independent of body size and by doing this will determine whether DR has health benefits for women over and above any benefit gained as a result of weight loss. The primary hypotheses to be tested are: l) psychometrically-measured dietary restraint is associated with significant reductions in total energy expenditure and energy intake in middle-aged women, as previously reported in young women, independent of level of physical activity and body composition; 2) dietary restraint, in combination with consumption of adequate intakes of protein, vitamins and minerals and independent of level of physical activity and body composition, is associated with alterations in a range of selected age-sensitive metabolic and physiologic variables, suggesting a reduced rate of biological aging in middle-aged women. The subjects will be 66 healthy post-menopausal women aged 55-62 years, with half classified as long-term restrained eaters and half classified as long- term unrestrained eaters. Group matching will be performed for body composition, level of physical activity, ancestral lifespan and other factors influencing morbidity and mortality. In an all day study, determinations will be made of usual nutrient intakes, free-living total energy expenditure, resting metabolic rate, body composition (body fat, lean body mass, total bone mineral, and fat distribution), immune function (in vivo delayed-type hypersensitivity, in vitro T-cell mitogen stimulation of lymphocytes, and cytokine and prostaglandin E2 production by lymphocytes), insulin resistance, circulating insulin-like growth factor 1, thyroid status, blood lipid profile (total cholesterol, HDL, LDL, VLDL and triglycerides), and cardiopulmonary function (maximum oxygen consumption, blood pressure, forced vital capacity and forced expiratory volume in l second). The effects of dietary restraint will be evaluated by comparing results in the two groups using standard statistical techniques. We anticipate that the results of this investigation may have far-reaching consequences with regard to the role of DR in maintaining long-term health in the adult population.