EFFECTS OF AGING ON THERMIC EFFECT OF FEEDING

这项研究的具体目标是-- 1)为了验证衰老与体温降低有关的假设， 饲养效果（TEF）。 这一假设将在一项研究中得到检验， 健康的年轻和老年妇女被喂食含有四种 不同水平的能量摄入（0，250，500，1000千卡），TEF是 随访直至恢复至基线，以确定剂量反应是否 TEF和底物氧化的关系和/或时间过程不同 随年龄 将对年轻女性进行重复测量， 月经周期的阶段可能会影响TEF。 2)为了确定可能导致TEF降低的因素， 通过检查TEF、体脂含量和 分布、适应性（VO 2 max）、胰岛素敏感性、底物使用， 交感神经系统活动和甲状腺激素。

The specific aims of this study are-- 1) To test the hypothesis that aging is associated with decreased themic effect of feeding (TEF). This hypothesis will be tested in a study in which healthy young and elderly women are fed test meals containing four different levels of energy intake (0, 250, 500, 1000 kcals), and TEF is followed until a return to baseline to determine whether the dose-response relationship and/or the time course of TEF and substrate oxidation differs with age. Repeated measurements will be made on the young women due to the possibility that the stage of the menstrual cycle may influence TEF. 2) To determine the factors that may cause a decrease in TEF in the elderly by examinig associations between TEF, body fat content and distribution, fitness (VO2max), insulin sensitivity, substrate use, sympathetic nervous system activity, and thyroid hormone.