ILLUMINATION IN HUMAN AGING--SLEEP AND MOOD EFFECTS

大多数上了年纪的美国人经历了更多的客观困扰 启动和维持睡眠。失眠的抱怨是最多的 老年人住院和过早死亡的重要风险因素 老年人。同样，抑郁症状是结肠癌和高度瘫痪，以及 美国老年人的自杀率正在上升。一个正在进行的 调查显示，日光暴露不足与 40-年龄段成年人的失眠和抑郁症状。 初步研究和理论论证表明，失眠和 美国老年人的抑郁症部分是由光线不足引起的 曝光。这项研究将调查低照度的流行情况。 圣地亚哥60-79岁人群代表性样本的暴露情况 几年，并将评估光照与 睡眠和抑郁症状。在实验室临床试验中，135 60-79岁的志愿者将在以下时间度过5晚4天 受控的照明条件。通过分层随机化，三分之一的 受试者将被分配到两个实验治疗中的每一个，使用3000 每天用勒克斯强光照射4小时。最后三分之一的受试者将 接收控件50 Lux灯光和安慰剂暗淡红光治疗。每门课都会是 监测8小时睡眠期间的多导睡眠图以确定 强光治疗对客观睡眠障碍的益处。 将收集尿液以确定治疗效果。 褪黑激素排泄的昼夜节律。主观睡眠记录和情绪 自我评级将评估治疗的主观益处。通过 展示了强光带来的偶然好处，这个实验将会发展 对数百万美国老年人具有潜在高影响的治疗。

Most aging Americans experience increased objective disturbances of initiating and maintaining sleep. Insomnia complaints are among the most important risk factors for institutionalization and early death among the elderly. likewise, depressive symptoms are colon and highly disabling, and the rate of suicide is increasing among elderly Americans. An ongoing survey shows that inadequate daylight exposures are associated with insomnia and depressive symptoms among adults 40-64 year of age. Preliminary studies and theoretical arguments indicate that insomnia and depression in aging Americans are partly caused by inadequate light exposure. This study will survey the prevalence of low illumination exposure in a representative sample of the San Diego population ages 60-79 years and will assess the epidemiologic associations of illumination with sleep and depressive symptoms. In a laboratory clinical trial, 135 volunteer subjects ages 60-79 will spend 5 nights and 4 days under controlled lighting conditions. With stratified randomization, 1/3 of subjects will be assigned to each of two experimental treatments using 3000 lux bright light for 4 hours each day. The final 1/3 of subjects will receive control 50 lux lighting and placebo dim red light treatment. Each subject will be monitored polysomnographically during the 8-hour sleep periods to determine the benefits of bright light treatment on objective sleep disturbances. Urine collections will be obtained to determine treatment effects on the circadian rhythm of melatonin excretion. Subjective sleep logs and mood self-ratings will assess subjective benefits of the treatments. By demonstrating casual benefits of bright light, this experiment will develop treatments with potentially high impact for millions of elderly Americans.