Salmonella in poultry: improving vaccine efficacy

该项目的中心目标是提高aroA突变型鼠伤寒沙门氏菌疫苗的抗原性，特别是生物特性公司的Vaxsafe®ST.抗原性的提高将影响肠道微生物群，刺激更强的宿主免疫反应，提高疫苗的效力，并延长对家禽鼠伤寒沙门氏菌的保护时间。这将最终减少农场环境中的细菌负荷，减轻食品供应链的下游污染，并减少人类沙门氏菌病病例的数量。

The central aim of this project is to increase the antigenicity of aroA mutant Salmonella Typhimurium vaccines, in particular Bioproperties’ Vaxsafe® ST. Increased antigenicity will affect the gut microbiota and stimulate a stronger host immune response improving vaccine efficacy and the duration of protection against S. Typhimurium in poultry. This will ultimately reduce bacterial loads in the farm environment, mitigate downstream contamination of the food supply chain, and reduce the number of human salmonellosis cases.