The Fluid-Particle Mechanics of a Synthetic Jet-based Dry Powder Inhaler

本项目旨在解开一种新概念芯片微零净质量流量(Micro-ZNMF)喷射辅助干粉吸入器(DPI)中控制流体力学和颗粒相互作用的基本原理。呼吸系统疾病影响着620万澳大利亚人。这些疾病的治疗受到当前给药系统效率低下的阻碍，传统的DPI设备表现出次优性能，通常不到负载剂量的20%到目标部位，即肺部。这项研究产生的新的基础知识将使设计一个高效、突破性的DPI成为可能，具有完全适应特定用户的潜力，使数百万澳大利亚人受益。

This project aims to untangle the fundamental principles that govern the fluid mechanics and particulate interactions in a novel concept chip-based micro-zero-net-mass-flux (micro-ZNMF) jet-assisted dry powder inhaler (DPI). Respiratory diseases affect 6.2 million Australians. The treatment of these diseases is hampered by the poor efficiency of current delivery systems, with conventional DPI devices exhibiting sub-optimum performance, delivering typically less than 20% of the loaded dose to the target site, the lungs. The new fundamental knowledge resulting from this research will enable the engineering of a high-efficiency groundbreaking DPI, with the potential to be fully adaptive user-specific benefiting millions of Australians.