Characterising the transport and delivery of oligonucleotides

短RNA和DNA分子代表了一类具有巨大潜力的大分子，但要促进它们跨越细胞和膜屏障进入特定的作用部位是具有挑战性的。该项目旨在开发和应用新的成像方法来在细胞和组织中跟踪它们。预期的结果包括更好地了解跨越细胞和膜屏障的运输，以及改进的成像工具，可用于进一步研究这些分子积累、代谢和运输的分子机制。该项目应该提供新的策略，将这些分子定向到特定的细胞和组织，这些细胞和组织对澳大利亚社区具有显著的社会和经济效益。

Short RNA and DNA molecules represent a class of macromolecules that have great potential, but to facilitate their trafficking across cellular and membrane barriers into specific sites of action is challenging. This project aims to develop and apply novel imaging approaches to track them in cells and tissues. Expected outcomes include better understanding of the trafficking across cellular and membrane barriers, and improved imaging tools that could be used to further study the molecular mechanisms of accumulation, metabolism and trafficking of these molecules. This project should provide new strategies to target these molecules to specific cells and tissues, which have significant social and economic benefits to the Australian community.