课题基金 / 基金详情

TREATMENT OF TB WITH MICROENCAPSULATED DRUGS

TREATMENT OF TB WITH MICROENCAPSULATED DRUGS
用微胶囊药物治疗结核病
批准号：
2075134
负责人：
William W Barrow
金额：
$36.22万
依托单位：
SOUTHERN RESEARCH INSTITUTE
依托单位国家：
美国
项目类别：
财政年份：
1995
资助国家：
美国
项目状态：
已结题
起止时间：
1995-08-01 至 1999-07-31
来源：
https://reporter.nih.gov/project-details/2075134
关键词：
antitubercular agents drug design /synthesis /production drug screening /evaluation ethambutol isoniazid laboratory mouse lymphocyte proliferation microcapsule phagocytosis rifamycins streptomycin tissue /cell culture

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中文摘要
翻译
描述：（改编自申请人摘要）。结核病是一个重要的 感染在世界范围内，其发病率在美国正在增加。S.在 鉴于此，人们对发展 有效对抗感染的新药物或递送系统 来提高病人的存活率本申请涉及开发 微囊化抗结核药物的研究， 上述目标。一旦开发出来，这些药物将在 体外，使用鼠巨噬细胞系和人单核细胞 线之后，这些药物将在感染MTB的小鼠中进行测试。
英文摘要
DESCRIPTION: (Adapted from Applicant's Abstract). TB is an important infection worldwide and its incidence is increasing in the U. S. In view of this, much interest has been directed to the development of novel drugs or delivery systems that are effective against the infection to improve patient survival. This application deals with the development of microencapsulated anti-TB drugs with the hope of accomplishing the aforementioned goal. Once developed, these drugs will be tested in vitro, using a murine macrophage cell line and a human monocytic cell line. Afterwards, the drugs will be tested in mice infected with MTB.
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