DIGITAL BREAST SPECIMEN RADIOGRAPHY FOR IMPROVED BIOPSY

该提案的目的是开发一种紧凑的、无胶片的电子X-射线照相机。 射线成像系统，用于高分辨率乳腺标本摄影。 这 该器械预期用于手术室中的快速X线摄影， 切除的乳腺标本，以及放射学中的针芯活检 程序. 这种方法将使外科医生和放射科医生能够查看 在打电话的同时电脑显示器上的图像 协商 预计这种方法将节省大量资金 宝贵的手术室时间，并将几乎消除对 外科医生在没有立即可用的情况下做出决定 标本X线片。 拟议的研究将调查使用一种 1024 x1024像素分辨率的CCD，可检测光发射 响应于X射线束从精细细节X射线增感屏 由微焦点X射线源引导。 一种配置将是 透镜耦合方法，其中X射线增感屏是光学的 耦合到CCD使用快速镜头，另一种配置将使用光纤 增强屏和CCD之间的光学耦合。 系统 将被设计为提供上级图像质量， 传统的基于胶片的样本射线照相系统。 建议的商业应用：8，000至10，000例乳腺活检 每年在美国举行。目前，没有专门的无胶片 试样射线照相系统是市售的。 鉴于 无胶片X线摄影的优点，特别是对于小视场 应用程序，我们预计在这项技术的强烈的商业兴趣。

The aim of this proposal is to develop a compact, filmless, electronic x- ray imaging system for high resolution breast specimen radiography. This device is intended for use in the operating room for rapid radiography of excisional breast specimens, and in radiology for needle core biopsy procedures. This approach will enable the surgeon and radiologist to view the image on a computer monitor simultaneously during telephone consultation. It is anticipated that this method will save extremely valuable operating room time and will virtually eliminate the need for the surgeon to make a decision without the immediate availability of a specimen radiograph. The proposed research will investigate the use of a CCD with 1024x1024 pixel resolution, which will detect the light emission from a fine detail x-ray intensifying screen in response to an x-ray beam directed from a micro focus x-ray source. One configuration will be a lens-coupled approach, where the x-ray intensifying screen is optically coupled to a CCD using fast lenses, the other configuration will use fiber optic coupling between the intensifying screen and the CCD. The system will be designed to provide superior image quality as compared to conventional film-based specimen radiography systems. PROPOSED COMMERCIAL APPLICATION: 8,000 to 10,000 breast biopsies are performed each year in the United States. Currently, no dedicated filmless specimen radiography system is commercially available. Given the advantages of filmless radiography, especially for small field-of-view applications, we expect strong commercial interest in this technology.