Novel tetrahedron beam CT for point-of-care imaging in ear, nose and throat imaging

新型四面体束 CT，用于耳鼻喉成像中的护理点成像

• 批准号: 10688182
• 负责人: Emre Toker
• 金额: $ 75.05万
• 依托单位: TETRAIMAGING, LLC
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-09-30 至 2024-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10688182
• 关键词: Academy; Address; Advanced Development; Algorithms; American; Benchmarking; Calibration; Clinic; Clinical; Complement; Dedications; Development; Diagnosis; Diagnostic; Diagnostic Imaging; Disease; Dose; Ear; Evaluation; Exposure to; Future; Geometry; Goals; Head and Neck Surgery; Head and neck structure; Image; Image-Guided Surgery; Inferior; Intervention; Legal patent; Malignant Neoplasms; Marketing; Medical; Metals; Morphologic artifacts; Noise; Nose; Nose Cancer; Operative Surgical Procedures; Otolaryngologist; Otolaryngology; Outcome; Outcomes Research; Patients; Performance; Pharyngeal structure; Phase; Point-of-Care Systems; Process; Qualitative Evaluations; Quantitative Evaluations; Radiation Dose Unit; Radiation exposure; Radiation therapy; Research; Roentgen Rays; Rotation; Scanning; Sinus; Slice; Small Business Technology Transfer Research; Soft Tissue Disorder; Source; Speed; Structure; System; Systems Integration; Technology; Therapeutic Intervention; Throat Cancer; Vendor; Visit; X-Ray Computed Tomography; X-Ray Medical Imaging; commercial application; commercialization; cone-beam computed tomography; cost; design; detector; experience; image guided intervention; image guided radiation therapy; image reconstruction; imager; imaging modality; imaging study; improved; innovation; maxillofacial; novel; phase 1 study; phase 2 study; photon-counting detector; point of care; point-of-care diagnostics; prototype; research clinical testing; seal; soft tissue; voltage

ABSTRACT Point-of-care imaging is highly desired in otolaryngologic clinics for the diagnosis of ear, nose and throat (ENT) diseases including cancers. Due to limited image quality, current cone-beam CT (CBCT) products act not as a substitute but rather as a complement to diagnostic Multi-slice CT (MSCT) in maxillofacial and ENT imaging. The emerging multi-source x-ray source technology suggests new designs of CT systems that may have faster imaging speed, improved image quality, reduced radiation exposure, and compact geometries. Tetrahedron Beam Computed Tomography (TBCT) is a compact volumetric CT based on linear array multi- pixel x-ray sources which can produce diagnostic-quality volumetric images but in a much more compact geometry than CBCT. During Phase I study, we successfully developed a benchtop ENT-TBCT system using a multi-pixel thermionic emission x-ray (MPTEX) source developed in-house and a state-of-art commercial photon-counting detector (PCD), and demonstrated the superior image quality that TBCT can achieve. During the Phase II study, we will further refine the MPTEX source and develop a clinical prototype system. To achieve this goal, we propose to perform studies to achieve the following Specific Aims (SA): SA 1: To develop a rotatable sealed MPTEX source; SA 2: To develop a clinical ENT-TBCT prototype on a rotating gantry; and SA 3: To develop advanced image reconstruction algorithm and perform benchmark imaging studies. The outcome of this research will be a highly effective point-of-care diagnostic imaging modality for otolaryngologic clinics. Future commercialization of the ENT-TBCT system will improve the quality and efficacy by supporting prompt diagnosis and treatment of ENT cancers and other diseases.

摘要 床旁成像是非常需要在耳鼻喉科诊所的诊断耳，鼻，喉 (ENT)包括癌症在内的疾病。由于图像质量有限，目前的锥束CT（CBCT）产品 多层螺旋CT（MSCT）在颌面和耳鼻喉科的诊断中不是替代而是补充 显像新兴的多源X射线源技术提出了CT系统的新设计， 具有更快的成像速度、改进的图像质量、减少的辐射暴露和紧凑的几何形状。 四面体射束计算机断层扫描（TBCT）是一种基于线阵多路扫描的紧凑型容积CT， 像素X射线源可以产生诊断质量的体积图像， 几何比CBCT。在第一阶段的研究中，我们成功地开发了一个台式ENT-TBCT系统 使用内部开发的多像素电子发射X射线（MPTEX）源和最先进的 商业光子计数探测器（PCD），并证明了优越的上级图像质量，TBCT可以 achieve.在第二阶段的研究中，我们将进一步完善MPTEX来源，并开发临床 原型系统为达致这个目标，我们建议进行研究，以达致以下具体目标： 目的（SA）：SA 1：开发可旋转密封MPTEX源; SA 2：开发临床ENT-TBCT 旋转机架上的原型; SA 3：开发高级图像重建算法并执行 基准成像研究。这项研究的结果将是一个非常有效的即时诊断 耳鼻喉科临床的成像模式。ENT-TBCT系统的未来商业化将得到改善 通过支持耳鼻喉癌症和其他疾病的及时诊断和治疗，提高质量和疗效。

项目成果

Simulation study of a novel small animal FLASH irradiator (SAFI) with integrated inverse-geometry CT based on circularly distributed kV X-ray sources.

• DOI: 10.1038/s41598-023-47421-0
• 发表时间: 2023-11-17
• 期刊: SCIENTIFIC REPORTS
• 影响因子: 4.6
• 作者: Tan, Yuewen;Zhou, Shuang;Haefner, Jonathan;Chen, Qinghao;Mazur, Thomas R.;Darafsheh, Arash;Zhang, Tiezhi
• 通讯作者: Zhang, Tiezhi