Novel tetrahedron beam CT for point-of-care imaging in ear, nose and throat imaging

新型四面体束 CT，用于耳鼻喉成像中的护理点成像

• 批准号: 10546823
• 负责人: Emre Toker
• 金额: $ 116.84万
• 依托单位: TETRAIMAGING, LLC
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-09-30 至 2024-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10546823
• 关键词: Academy; Address; Advanced Development; Algorithms; American; Benchmarking; Calibration; Clinic; Clinical; Complement; Development; Diagnosis; Diagnostic; Diagnostic Imaging; Disease; Dose; Ear; Evaluation; Exposure to; Future; Geometry; Goals; Head and Neck Surgery; Head and neck structure; Image; Image-Guided Surgery; Inferior; Intervention; Legal patent; Malignant Neoplasms; Medical; Metals; Morphologic artifacts; Noise; Nose; Nose Cancer; Operative Surgical Procedures; Otolaryngologist; Otolaryngology; Outcome; Outcomes Research; Patients; Performance; Pharyngeal structure; Phase; Point-of-Care Systems; Procedures; Process; Qualitative Evaluations; Quantitative Evaluations; Radiation Dose Unit; Radiation exposure; Radiation therapy; Research; Roentgen Rays; Scanning; Sinus; Slice; Small Business Technology Transfer Research; Soft Tissue Disorder; Source; Speed; Structure; System; Systems Integration; Technology; Throat Cancer; Vendor; Visit; X-Ray Computed Tomography; X-Ray Medical Imaging; base; commercial application; commercialization; cone-beam computed tomography; cost; design; detector; experience; image guided intervention; image guided radiation therapy; image reconstruction; imager; imaging modality; imaging study; improved; innovation; maxillofacial; novel; phase 1 study; phase 2 study; photon-counting detector; point of care; point-of-care diagnostics; prototype; research clinical testing; seal; soft tissue; voltage

ABSTRACT Point-of-care imaging is highly desired in otolaryngologic clinics for the diagnosis of ear, nose and throat (ENT) diseases including cancers. Due to limited image quality, current cone-beam CT (CBCT) products act not as a substitute but rather as a complement to diagnostic Multi-slice CT (MSCT) in maxillofacial and ENT imaging. The emerging multi-source x-ray source technology suggests new designs of CT systems that may have faster imaging speed, improved image quality, reduced radiation exposure, and compact geometries. Tetrahedron Beam Computed Tomography (TBCT) is a compact volumetric CT based on linear array multi- pixel x-ray sources which can produce diagnostic-quality volumetric images but in a much more compact geometry than CBCT. During Phase I study, we successfully developed a benchtop ENT-TBCT system using a multi-pixel thermionic emission x-ray (MPTEX) source developed in-house and a state-of-art commercial photon-counting detector (PCD), and demonstrated the superior image quality that TBCT can achieve. During the Phase II study, we will further refine the MPTEX source and develop a clinical prototype system. To achieve this goal, we propose to perform studies to achieve the following Specific Aims (SA): SA 1: To develop a rotatable sealed MPTEX source; SA 2: To develop a clinical ENT-TBCT prototype on a rotating gantry; and SA 3: To develop advanced image reconstruction algorithm and perform benchmark imaging studies. The outcome of this research will be a highly effective point-of-care diagnostic imaging modality for otolaryngologic clinics. Future commercialization of the ENT-TBCT system will improve the quality and efficacy by supporting prompt diagnosis and treatment of ENT cancers and other diseases.

抽象的 耳鼻喉科诊所非常需要床旁成像来诊断耳、鼻和喉咙 （耳鼻喉科）疾病，包括癌症。由于图像质量有限，当前的锥束 CT (CBCT) 产品表现不佳 不是替代，而是作为颌面和耳鼻喉科诊断性多层 CT (MSCT) 的补充 成像。新兴的多源 X 射线源技术提出了 CT 系统的新设计，可能 具有更快的成像速度、更高的图像质量、更少的辐射暴露和紧凑的几何形状。 四面体束计算机断层扫描 (TBCT) 是一种基于线性阵列多面体的紧凑型体积 CT 像素 X 射线源，可以产生诊断质量的体积图像，但尺寸更加紧凑 几何学优于 CBCT。在一期研究中，我们成功开发了台式 ENT-TBCT 系统 使用内部开发的最先进的多像素热电子发射 X 射线 (MPTEX) 源 商用光子计数探测器（PCD），并展示了 TBCT 的卓越图像质量 达到。在II期研究期间，我们将进一步完善MPTEX来源并开发临床 原型系统。为实现这一目标，我们建议进行研究以实现以下具体目标 目标 (SA)：SA 1：开发可旋转密封 MPTEX 源； SA 2：开发临床 ENT-TBCT 旋转龙门上的原型； SA 3：开发先进的图像重建算法并执行 基准成像研究。这项研究的结果将是一种高效的即时诊断 耳鼻喉科诊所的成像模式。 ENT-TBCT系统未来的商业化将得到改善 通过支持耳鼻喉癌症和其他疾病的及时诊断和治疗来提高质量和功效。