SEEM: Sensor-Enabled Emotion Monitoring Eyewear

帕金森病影响全球3000万人（Frederico et al, 2012），是第二常见的神经退行性疾病。症状包括震颤、丧失面部表情、丧失声音突出、肌肉僵硬、下降姿势、行走困难。在英国，每年有1万例帕金森氏症（PD）新病例。帕金森氏症难以治愈的一个原因是，运动症状（如震颤）只有在神经细胞开始死亡多年后才会出现（70-80%的神经细胞已经消失）。我们对这些早期阶段的了解还不够，尽管很明显，一些症状可能在帕金森症的运动问题出现前20年就出现了。临床医生只能看到病人日常生活的“薄片”，因此在信息非常有限的情况下做出重要的管理决策。我们正在开发一种可穿戴技术，以识别可能值得进一步调查和治疗的患者子集。目前，由于无法客观和远程监测治疗反应或恶化，无法进行个性化治疗，并由于过量用药、治疗不足和生活质量差而导致不必要的并发症。

Parkinson's Disease affects 30 million people worldwide (Frederico et al 2012) and is the second commonest neurodegenerative disorder. Symptoms include tremors, loss of facial expressivity, loss of vocal projection, muscle rigidity, dropping posture, walking difficulty. There are 10,000 new cases of Parkinson’s disease (PD) each year in the UK. One reason why a cure for Parkinson’s is elusive is because the movement symptoms (e.g. tremor) only appear many years after the nerve cells start dying (70-80% of the nerve cells are already been lost by then). We do not know enough yet about these early stages, although it is clear that some symptoms may occur up to 20 years before the movement problems of Parkinson's appear. A clinician will only ever see a 'thin slice' of a patient's daily life and therefore is making important decisions about management with very limited information. We are developing a wearable technology to identify a subset of patients who might merit further investigation and treatment. Currently, the inability to objectively and remotely monitor treatment response or deterioration does not enabled personalised treatments and leads to unnecessary complications due to over-dosing, inadequate treatment and poor quality of life.