Lactam based biofilm-ready surfaces with cross-industry application

家庭护理、造纸和海洋行业的卫生越来越具有挑战性。家庭、工业、医院和海洋表面不断受到微生物污染的挑战。目前的抗微生物药物，如金属和Quats，存在环境和毒理学风险，对生物膜的效果有限，同时存在增加微生物耐药性的风险。生物衍生的内酰胺类药物在生物被膜的生长和发育过程中干扰群体感应，显然没有驱动耐药性。最近的可行性研究证明了内酰胺类化合物作为纺织品抗生物膜涂层的潜力(TSB132177)。到目前为止，由于生物利用度和配方障碍，它们在液体产品中作为活性成分的有效性有限。在制造和整理过程中使用不同的应用技术，铅类似物将定位于纸巾、纸张、海洋和其他工业表面。该项目将建立一个商业案例，并基于成本、有效性和稳健性为跨行业表面生物膜破坏推荐高效的结合化学和工艺路线。成功的应用示范将加快内酰胺商业化的步伐，使工业合作伙伴的市场份额和收入增加，并为ROS实现知识产权和出版货币化。

Hygiene in homecare, paper and marine industries is increasingly challenging. Home, industrial, hospital and marine surfaces are constantly challenged by microbial contamination. Current anti-microbials such as metals and quats present environmental and toxicological risks, are of limited efficacy on biofilms, whilst presenting a risk of increasing microbial resistance. Bioderived lactams disrupt quorum sensing during biofilm growth and development apparently without driving resistance. Recent feasibility work demonstrated the potential of lactams as anti-biofilm coatings on textiles (TSB132177). To date, their efficacy as active ingredients in liquid products is limited due to bioavailability and formulation hurdles. Using diverse application techniques during manufacture and finishing, lead analogues will be localised on wipes, paper, marine, and other industrial surfaces. The project will build a business case and recommend efficient incorporation chemistry and process route for cross-industry surface biofilm disruption based on cost, efficacy and robustness. Successful demonstration of application will fast track lactam commercialisation allowing market share and revenue gains for industrial partners and IP and publication monetisation for ROs.