MATERNAL DIET AND RISK OF BRAIN TUMOR IN CHILDREN

这项拟议的研究将调查母亲的饮食在 妊娠和儿童早期饮食中一种特定类型的病因学 儿童脑癌，原始神经外胚层肿瘤(PNET)。这个 要检验的假设是基于我们先前研究的结果 其中PNET对水果有强烈而显著的保护作用， 观察蔬菜、维生素C和叶酸的摄入量。复合维生素 怀孕早期的补充剂和铁的补充剂似乎也能 降低风险。本提案旨在复制和扩展这些内容 在方法上更严格的研究中的发现。母亲的饮食将 使用食物频率问卷进行全面评估，该问卷具有 已在多个环境中广泛使用和验证。早期的几个方面 儿童饮食也将作为可能的危险因素进行研究，以及 母体饮食的可能影响因素或混杂因素。二 将进行子研究以调查有效性和 关于饮食报告的食物频率问卷的重复性 在过去长达11年的怀孕期间。调查结果： 子研究将被用来解释饮食结果。 另一个目的是调查其他建议的风险因素的作用， 包括生育史、父母职业和农场居住地。 这项研究将使用病例对照设计，将包括400例病例和 400名配对对照。病例将是以前被诊断为PNET的儿童 6岁，在儿童癌症组织注册，是两个人之一 在美国的儿科肿瘤学临床试验小组将控制 通过随机数字拨号选择，并与年龄、种族和 地理区域。关于母亲饮食、儿童饮食和其他因素的数据 将通过电话采访的方式收集。 饮食与儿童癌症的关系研究很少。这个 拟议的研究将提供有关母婴饮食的作用的数据 在一种组织学类型的儿童癌症的病因学中，还将 对调查怀孕和早期的方法做出贡献 回顾童年饮食。

The proposed study will investigate the role of maternal diet during pregnancy and early childhood diet in the etiology of a specific type of childhood brain cancer, primitive neuroectodermal tumor (PNET). The hypotheses to be tested are based on results from our previous study of PNET in which strong and significant protective effects of fruit, vegetable, vitamin C, and folate intake were observed. Multivitamin supplements early in pregnancy and iron supplements also appeared to decrease risk. This proposal intends to replicate and extend these findings in a methodologically more rigorous study. Maternal diet will be assessed comprehensively using a food frequency questionnaire that has been widely used and validated in several settings. Aspects of early childhood diet will also be studied as possible risk factors as well as possible effect modifiers or confounders of maternal diet. Two substudies will be conducted to investigate the validity and reproducibility of the food frequency questionnaire for reporting on diet during a pregnancy up to 11 years in the past. The findings of the substudies will be used in the interpretation of the dietary results. Another aim is to investigate the role of other suggested risk factors, including reproductive history, parental occupation, and farm residence. The study will use a case-control design and will include 400 cases and 400 matched controls. Cases will be children diagnosed with PNET before age 6 and registered with the Children's Cancer Group, one of two pediatric oncology clinical trials groups in the U.S. Controls will be selected by random-digit-dialing and matched to cases on age, race, and geographic area. Data on maternal diet, child diet, and other factors will be collected by telephone interview. Diet has been studied little in relation to childhood cancer. The proposed study will provide data on the role of maternal and child diet in the etiology of one histologic type of childhood cancer and will also contribute to the methodology of investigating pregnancy and early childhood diet retrospectively.