MATERNAL DIET AND RISK OF BRAIN TUMOR IN CHILDREN

这项拟议的研究将调查母亲饮食在怀孕期间的作用。 妊娠和幼儿饮食中的一种特殊类型的病因 儿童脑癌、原始神经外胚层肿瘤（PNET）。 的 待检验的假设是基于我们以前的研究结果， 其中PNET对水果有较强而显著的保护作用， 观察蔬菜、维生素C和叶酸摄入量。 多种维他命 补充剂和铁补充剂也似乎 降低风险。 该提案旨在复制和扩展这些 这是一项在方法上更严格的研究。 产妇饮食会 使用食物频率问卷进行全面评估， 已在多个环境中得到广泛使用和验证。 早期方面 儿童饮食也将作为可能的风险因素进行研究， 可能的影响因素或母体饮食的混杂因素。 两 将进行子研究以调查有效性， 用于报告饮食的食物频率问卷的再现性 在过去的11年里怀孕。 的调查结果 子研究将用于解释饮食结果。 另一个目的是调查其他建议的风险因素的作用， 包括生育史、父母职业和农场居住地。 该研究将采用病例对照设计，将包括400例病例， 400个匹配对照。 病例将是以前诊断患有PNET的儿童 6岁，在儿童癌症组织注册，是两个 美国儿科肿瘤学临床试验组的控制将是 通过随机数字拨号选择，并与年龄，种族和 地理区域。 关于母亲饮食、儿童饮食和其他因素的数据 将通过电话采访收集。 饮食与儿童癌症的关系研究很少。 的 一项拟议的研究将提供有关母婴饮食作用的数据 在一种组织学类型的儿童癌症的病因学中， 有助于调查怀孕和早期 童年饮食回顾

The proposed study will investigate the role of maternal diet during pregnancy and early childhood diet in the etiology of a specific type of childhood brain cancer, primitive neuroectodermal tumor (PNET). The hypotheses to be tested are based on results from our previous study of PNET in which strong and significant protective effects of fruit, vegetable, vitamin C, and folate intake were observed. Multivitamin supplements early in pregnancy and iron supplements also appeared to decrease risk. This proposal intends to replicate and extend these findings in a methodologically more rigorous study. Maternal diet will be assessed comprehensively using a food frequency questionnaire that has been widely used and validated in several settings. Aspects of early childhood diet will also be studied as possible risk factors as well as possible effect modifiers or confounders of maternal diet. Two substudies will be conducted to investigate the validity and reproducibility of the food frequency questionnaire for reporting on diet during a pregnancy up to 11 years in the past. The findings of the substudies will be used in the interpretation of the dietary results. Another aim is to investigate the role of other suggested risk factors, including reproductive history, parental occupation, and farm residence. The study will use a case-control design and will include 400 cases and 400 matched controls. Cases will be children diagnosed with PNET before age 6 and registered with the Children's Cancer Group, one of two pediatric oncology clinical trials groups in the U.S. Controls will be selected by random-digit-dialing and matched to cases on age, race, and geographic area. Data on maternal diet, child diet, and other factors will be collected by telephone interview. Diet has been studied little in relation to childhood cancer. The proposed study will provide data on the role of maternal and child diet in the etiology of one histologic type of childhood cancer and will also contribute to the methodology of investigating pregnancy and early childhood diet retrospectively.