IMPLANTABLE RAT AND MOUSE BLOOD PRESSURE TRANSDUCER

长期目标是开发压力传感器， 大鼠和小鼠的慢性植入。 具体目标：开发直径为1.3 mm的 大鼠植入式换能器;植入式匹配圆顶/套管/冲洗 用于鼠标的系统;以及用于与监控接口的辅助电子设备 系统. 大鼠和小鼠正在取代心脏研究中的大型哺乳动物 和社会原因。 无合适的慢性植入式压力制剂 现在可以使用。 植入式传感器已被证明 显著降低实验动物死亡率和发病率， 允许更长的监测时间，更高质量的数据。 实现目标的方法：设计/采购0.23 × 0.30毫米应变计 设计/制造1.3 mm直径传感器;开发新的金属/半导体 接口，以减少基线漂移。 所提出的1.3 mm植入式原型换能器可以在 一阶段 成功将证明第二阶段目标的可行性：经济 生产设计;植入式低顺应性圆顶/套管系统， 鼠标;支持电子设备。 较大尺寸植入式器械的经验 传感器已经显示出这种技术的扩展， 其他物种/器官应用中的配置。

Long term objective is to develop pressure transducer preparations for chronic implantation in rats & mice. Specific aims: develop a 1.3 mm dia implantable transducer for rats; implantable mating dome/cannula/flushing system for mice; & accessory electronics for interfacing with monitoring systems. Rats & mice are replacing larger mammals in cardiac research for budgetary & societal reasons. No suitable chronic implantable pressure preparations are now available. Implantable transducers have been shown to substantially reduce mortality & morbidity in experimental animals, permitting longer surveillance time, better quality data. Methodology for achieving goals: design/procure .23 x .30 mm strain gages; design/fabricate 1.3 mm dia transducers; develop new metal/semiconductor interface to reduce baseline drift. The proposed 1.3 mm implantable prototype transducer can be produced in Phase I. Success will justify feasibility of Phase II goals: economic production design; implantable low compliance dome/cannula systems for mice; support electronics. Experience with larger-sized implantable transducers has shown extension of such technology to innovative configurations in other species/organs applications.