Novel FMDV Vaccine Technology for Africa

口蹄疫病毒（FMDV）在大多数非洲国家流行。口蹄疫是一种感染牲畜的高度传染性和潜在致命性疾病。该病对非洲造成巨大的经济影响，因为它降低了农民的生产力及其出口农产品的能力，保守估计损失为8亿美元。口蹄疫病毒有不同的血清型，每种血清型都需要自己的疫苗来保护动物。每种血清型都被分成不同的毒株，这些毒株可以进化，因此它们也需要一种新的疫苗来预防它们。不同的血清型和毒株在非洲的不同区域有所不同，因此每个区域都需要自己的疫苗范围。撒哈拉以南非洲地区有口蹄疫疫苗，但它们目前不适合用于目的，因为：1)它们太昂贵；2)在许多非洲地区，它们不能防止流行毒株；3)它们必须反复接种；4)它们必须在不间断的冷链中冷藏，这对许多牲畜饲养者来说是不可能的。该项目将研究生产新的FMDV疫苗的可行性，这种疫苗比非洲目前的疫苗更便宜、生产更简单、更稳定、与流行毒株相匹配并且具有更好的区域覆盖率

Foot and Mouth disease virus (FMDV) is endemic in most African countries. FMD is a highly infectious and potentially fatal disease that infects livestock. The disease has a huge economic impact in Africa, as it reduces the productivity of farmers and their ability to export produce, with losses conservatively estimated at USD 800 million. There are different serotypes of FMDV, and each requires its own vaccine in order to protect animals. Each serotype is separated into different strains and these can evolve so that they too require a new vaccine to protect against them. The different serotypes and strains vary in different regions in Africa, so that each region requires its own range of vaccines. There are vaccines available for FMD in sub-Saharan Africa but they are not currently fit for purpose because: 1) they are too expensive, 2) in many African regions they do not protect against the circulating strains 3) they must be given repeatedly and 4) they must be kept refrigerated in an uninterrupted cold chain , which is not possible for many livestock keepers. The project will study the feasibility of producing new FMDV vaccines that are cheaper, simpler to produce, more stable, match circulating strains and have better regional coverage than the current vaccines in Africa