Organic Linchpin Reagents to Construct Structural Diversity and Complexity

高能化学物质，如碳烯、亚硝基或自由基，常被用作有机反应中的活性中间体，以迅速产生新的键、结构和结构复杂性。由于它们的反应性，传统上一次只能使用一种高能化学物质，以避免不必要的复杂副反应。本项目旨在开发含有多种不同类型的碳和亚硝基前体的新型合成底物。这些高能中间体可以通过控制正交刺激以接力方式释放，因此作为快速构建生物或光活性化合物和前所未有的复杂结构的关键试剂。

High-energy chemical species such as carbenes, nitrenes or free radicals are often used as reactive intermediates in organic reactions to rapidly generate new bonds, structures and structural complexities. Due to their reactive nature, traditionally only one type of high-energy chemical species can be featured at a time to avoid unwanted complicated side reactions. This project aims to develop novel synthetic substrates bearing multiple carbene and nitrene precursors of different types. These high-energy intermediates can be released in a relayed fashion by controlling orthogonal stimuli and therefore acting as linchpin reagents for quick construction of bio- or photo-active compounds and unprecedented complicated structures.