Exceptions Prove the Rule: How Antigen Recognition Drives T cell Activation

CD8+ T细胞是对适应性免疫反应至关重要的免疫细胞，是脊椎动物免疫功能的核心。CD8+ T细胞只有在激活后才能介导其效应功能，这是通过T细胞受体（TCR）对外来抗原的识别发生的。在这里，将使用独特的试剂和复杂的技术来精确定义tcr抗原识别的性质如何影响T细胞活化和效应功能。这项工作建立在早期发现的一种全新的tcr抗原识别模式的基础上，它的成功将在T细胞生物学中建立新的范式，并代表着生命科学知识的关键进步。

CD8+ T cells are immune cells that are critical for the adaptive immune response, which is central to immune function in vertebrates. CD8+ T cells mediate their effector functions only after activation, which occurs via T cell receptor (TCR) recognition of foreign antigens. Here, unique reagents and sophisticated technologies will be used to define precisely how the nature of TCR-antigen recognition impacts on T cell activation and effector function. This work builds on an earlier identification of an entirely novel mode of TCR-antigen recognition, and its success will establish novel paradigms in T cell biology and represent a key advance in knowledge in the life sciences.