EPIDEMIOLOGY OF INTERSTITIAL CYSTITIS

这是一项关于女性间质性膀胱炎的流行病学研究 两项大型队列研究的参与者：护士健康研究 第一阶段（121，000人参与）和第二阶段（116，000人参与 参与者）。间质性膀胱炎是一种慢性、疼痛和致残性疾病， 主要发生在妇女身上的疾病，但对它的了解却很少 甚至这些基本的流行病学因素，比如这种情况有多普遍， 疾病是在美国，如果它是在频率增加。主 目的是确定患病率、发病率和年龄 女性间质性膀胱炎的分布。次要目的 将是检查妇女的生活质量， 膀胱炎，将其与健康女性的生活质量进行比较， 对于那些患有其他慢性疼痛疾病的人，并探索 生活质量在四年内发生变化。 我们亦会研究 间质性膀胱炎与先前提出的风险之间的关系 自身免疫性疾病和多发性泌尿道疾病 感染.最后，我们将进行假设生成分析， 提出的风险因素，如雌激素的使用，饮食因素，和酒精 消费 关于医生诊断的间质性膀胱炎的信息 将通过两年一次的邮寄问卷收集。都是自我报告的 病例将通过补充表格和医疗检查确认。 记录诊断标准将是以前推荐的 NIDDK用于间质性膀胱炎的研究。信息 两年期调查表还将收集接触变量。 基线生活质量数据，使用医学结局研究简表 36，在本研究开始后两年内收集， 四年后更新。将获得额外的暴露信息 通过邮寄问卷调查所有的情况下，随机抽样500 对照在五年的随访中，超过110例 将确诊为间质性膀胱炎。大样本量和长 随访期将允许对患病率和发病率进行稳定估计 rates.此外，这将提供0.86的功效来检测相对 二分暴露的风险为1.8。这种慢性病的发病率 疾病，缺乏基本的流行病学信息和极端的 由于对风险因素的了解有限， 健康问题。拟议的研究将提供有关 间质性膀胱炎的频率，对生活质量的影响 患有这种疾病的女性，并将产生关于风险的假设 这种疾病的发展因素。

This is a study of the epidemiology of interstitial cystitis among female participants of two large ongoing cohort studies: the Nurses' Health Study I (121,000 participants) and Nurses' Health Study II (116,000 participants). Interstitial Cystitis is a chronic, painful and disabling disease occurring predominantly in women but remarkably little is known about even such basic epidemiologic factors such as how common this disease is in the US and if it is increasing in frequency. The primary objective will be to determine the prevalence, incidence rates, and age distribution of interstitial cystitis in women. The secondary objective will be to examine the quality of life of women with interstitial cystitis, to compare this to the quality of life of healthy women and also to those with other chronic, painful conditions, and explore how the quality of life changes over a four year period. We will also examine the relation between interstitial cystitis and previously proposed risk factors including autoimmune diseases and multiple urinary tract infections. Finally, we will perform hypotheses generating analyses on proposed risk factors such as estrogen use, dietary factors, and alcohol consumption. Information on the presence of physician diagnosed interstitial cystitis will be collected by biennial mailed questionnaire. All self-reported cases will be confirmed by a supplementary form and a review of medical records. The diagnostic criteria will be that previously recommended by the NlDDK for research studies of interstitial cystitis. Information on exposure variables will also be collected by the biennial questionnaire. Baseline quality of life data, using the Medical Outcomes Study Short-Form 36, were collected within two years of the start of this study and will be updated four years later. Additional exposure information will be obtained by mailed questionnaire from all the cases and a random sample of 500 controls. During the five years of follow-up, over 110 cases of interstitial cystitis will be confirmed. The large sample size and long follow-up period will permit stable estimates of prevalence and incidence rates. In addition, this will provide a power of 0.86 to detect a relative risk of 1.8 for a dichotomous exposure. The morbidity of this chronic disease, the lack of essential epidemiologic information and the extremely limited knowledge regarding risk factors makes this an important public health issue. The proposed study will provide valuable data on the frequency of interstitial cystitis, the impact on the quality of life of women with this disease, and will generate hypotheses regarding risk factors for the development of this disease.