EPIDEMIOLOGY OF INTERSTITIAL CYSTITIS

这是一项关于女性间质性膀胱炎的流行病学研究。 正在进行的两项大型队列研究的参与者：护士健康研究 I(121,000名参与者)和护士健康研究II(116,000名 参与者)。间质性膀胱炎是一种慢性、疼痛和致残的疾病。 疾病主要发生在女性身上，但人们对此知之甚少 甚至是这样的基本流行病学因素，比如这种情况有多普遍 疾病在美国，如果它的频率在增加。初级阶段 目标将是确定患病率、发病率和年龄 女性间质性膀胱炎的分布。次要目标 将检查女性间质病变的生活质量 膀胱炎，将其与健康女性的生活质量进行比较，还 给那些患有其他慢性痛苦疾病的人，并探索如何 生活质量在四年的时间里发生了变化。我们还将研究 间质性膀胱炎与先前提出的风险之间的关系 自身免疫性疾病和多尿路等因素 感染。最后，我们将执行假设生成分析 建议的风险因素，如雌激素使用、饮食因素和酒精 消费。 关于医生诊断为间质性膀胱炎的信息 将以每两年邮寄一次的问卷形式收集。所有人都自行报告 病例将通过补充表格和医疗复查来确认 唱片。诊断标准将是先前由 NlDDK用于间质性膀胱炎的研究。有关的信息 暴露变量也将由两年一次的调查问卷收集。 基线生活质量数据，使用《医疗结果研究简表》 36份，在这项研究开始后的两年内收集，并将 四年后更新。将获得更多曝光信息 通过邮寄所有病例的调查问卷和随机抽样500人 控制。在五年的随访中，超过110例 间质性膀胱炎将得到确认。样本量大、长度长 随访期将允许对流行率和发病率进行稳定的估计 费率。此外，这将提供0.86的功率来检测亲属 一分为二的风险为1.8。这一慢性疾病的发病率 疾病，缺乏必要的流行病学信息，以及极端 对风险因素的有限了解使这一点成为一个重要的公众 健康问题。拟议的研究将提供有关 间质性膀胱炎的频发，对生活质量的影响 患有这种疾病的妇女，并将产生关于风险的假设 导致这种疾病发展的因素。

This is a study of the epidemiology of interstitial cystitis among female participants of two large ongoing cohort studies: the Nurses' Health Study I (121,000 participants) and Nurses' Health Study II (116,000 participants). Interstitial Cystitis is a chronic, painful and disabling disease occurring predominantly in women but remarkably little is known about even such basic epidemiologic factors such as how common this disease is in the US and if it is increasing in frequency. The primary objective will be to determine the prevalence, incidence rates, and age distribution of interstitial cystitis in women. The secondary objective will be to examine the quality of life of women with interstitial cystitis, to compare this to the quality of life of healthy women and also to those with other chronic, painful conditions, and explore how the quality of life changes over a four year period. We will also examine the relation between interstitial cystitis and previously proposed risk factors including autoimmune diseases and multiple urinary tract infections. Finally, we will perform hypotheses generating analyses on proposed risk factors such as estrogen use, dietary factors, and alcohol consumption. Information on the presence of physician diagnosed interstitial cystitis will be collected by biennial mailed questionnaire. All self-reported cases will be confirmed by a supplementary form and a review of medical records. The diagnostic criteria will be that previously recommended by the NlDDK for research studies of interstitial cystitis. Information on exposure variables will also be collected by the biennial questionnaire. Baseline quality of life data, using the Medical Outcomes Study Short-Form 36, were collected within two years of the start of this study and will be updated four years later. Additional exposure information will be obtained by mailed questionnaire from all the cases and a random sample of 500 controls. During the five years of follow-up, over 110 cases of interstitial cystitis will be confirmed. The large sample size and long follow-up period will permit stable estimates of prevalence and incidence rates. In addition, this will provide a power of 0.86 to detect a relative risk of 1.8 for a dichotomous exposure. The morbidity of this chronic disease, the lack of essential epidemiologic information and the extremely limited knowledge regarding risk factors makes this an important public health issue. The proposed study will provide valuable data on the frequency of interstitial cystitis, the impact on the quality of life of women with this disease, and will generate hypotheses regarding risk factors for the development of this disease.