MI PBB COHORT 20 YEARS--ENDOCRINE DISRUPTION

描述：研究人员建议检查女性队列， 他们的后代暴露于多溴联苯（PBB）， 1973年，牛饲料污染。 密歇根州卫生部已经 对这群人进行了20多年的跟踪调查。 这些研究人员建议， 确定妇女出现的一些健康结果， 他们的后代，以确定是否有证据表明，内分泌 与多溴联苯接触有关的破坏。 电话采访将是 目前在队列中的大约1900名妇女接受了管理， 确定自接触内分泌敏感物质以来的累积发病率 终点，如子宫内膜异位症，良性乳腺疾病，异常巴氏涂片 涂片肌瘤和甲状腺功能障碍 在适当的亚组中， 他们将确定不孕症的累积发病率， 妊娠时间、哺乳期持续时间、自然流产率和 死胎、月经周期特征、绝经年龄，以及 髋部骨折的累积发病率。 在雌性后代中， 妇女，将确定初潮年龄和月经周期 特色 将审查医疗记录，以核实 临床条件。 这些结局的发生将通过以下方式建模： 多变量方法作为1976年多溴联苯血清水平的函数， 潜在的混淆变量

DESCRIPTION: The investigators propose to examine the cohort of women and their offspring who were exposed to polybrominated biphenyls (PBB) as a contaminant in cattle feed in 1973. The Michigan Department of Health has followed this cohort for more than 20 years. These investigators propose to ascertain the occurrence of a number of health outcomes in the women and their offspring in order to determine if there is evidence of endocrine disruption associated with PBB exposure. A telephone interview will be administered to approximately 1900 women currently in the cohort to ascertain the cumulative incidence since exposure of endocrine sensitive endpoints, such as endometriosis, benign breast disease, abnormal Pap smears, fibroids, and thyroid dysfunction. Among appropriate subgroups of the cohort, they will ascertain the cumulative incidence of infertility, time to pregnancy, duration of lactation, rates of spontaneous abortion and stillbirth, menstrual cycle characteristics, age at menopause, and cumulative incidence of hip fracture. In the female offspring of exposed women, determinations will be made of age at menarche and menstrual cycle characteristics. Medical records will be reviewed to verify each of the clinical conditions. The occurrence of these outcomes will be modeled by multivariate methods as a function of PBB serum level in 1976, controlling for potentially confounding variables.