Discovering New Chemistry and Potential Applications of Metal Tetrapyrroles

该项目旨在通过制备基于专门设计的四吡咯配体的新的含金属分子，在无机化学，配位化学和生物无机化学方面取得根本性进展。将开发创新的合成方法，以实现系统的化学修饰，以探索金属络合物的化学和生物学特性。将研究新分子作为分子成像示踪剂的潜力。这项研究的预期成果将是增加对化学性质如何决定金属络合物的生物活性的理解，从而为这种化学性质向新的分子诊断和治疗的潜在长期转化提供信息。

This project aims to make fundamental advances in inorganic chemistry, coordination chemistry and bioinorganic chemistry by preparing new metal-containing molecules based on specifically designed tetrapyrrole ligands. Innovative synthetic methods will be developed to enable systematic chemical modifications to explore the chemical and biological properties of the metal complexes. The potential of the new molecules to be of use as tracers for molecular imaging will be investigated. An expected outcome of this research will be an increased understanding of how chemical properties dictate the biological activity of metal complexes informing the potential long-term translation of this chemistry to to new molecular diagnostics and therapeutics.