REDLAB Going Global - REDucing LABoratory Rodent Numbers by driving adoption of UK Technology

转基因动物的创造，主要是小鼠和大鼠，彻底改变了对动物模型中疾病过程的理解。转基因生物技术利用大量的动物：雌性和雄性产生胚胎进行遗传操作，雌性提供宿主子宫以支持胚胎发育，不育雄性诱导受体雌性的“假孕”。仅在英国，2014年，120万只小鼠被用于转基因小鼠的育种计划。科学家需要遵守“三R”原则。（替换减少和改进）Ostara开发了一种专利的子宫托系统，该系统取代了输精管切除的男性在人工流产诱导中的使用并提高转基因胚胎在宿主母亲体内的植入率。该项目将在全球范围内展示和推广这项突破性技术：获得广泛传播、采用和测试的目标可以使小鼠数量减少80%。

The creation of genetically modified animals, primarily mice and rats, has revolutionised understanding of disease processes in animal models. Transgenic biotechnologies utilise large numbers of animals: females and males to generate embryos for genetic manipulation, females to provide a host uterus to support the development of embryos, and infertile males to induce ‘pseudopregnancy’ in recipient females. In the UK alone, 1.2 million mice were used in breeding programmes for production of transgenic mice in 2014.Scientists are required to comply with the principle of the “Three Rs” (Replacement Reduction andRefinement) to minimize the number of animals used in experimentation and to reduce pain and suffering.Ostara has developed a patented pessary system that supersedes the use of vasectomised males in theinduction of pseudopregnancy and enhances transgenic embryo implantation rates in the host mothers.The project will see this breakthrough technology demonstrated and promoted globally: the objective of gaining widespread dissemination, adoption and tests can produce an 80% reduction mice numbers.