SYNTHESIS OF POLYETHER ANTIBIOTICS/MONENSIN ANALOGS

这是该计划的目标，以开发高效，实用（内 所涉及的分子的复杂性的背景）的合成 聚醚离子载体。 这些抗生素用作离子/胺的试剂 运输，并通过其能力，以促进运输 生物相关离子（Na+、K+、CA 2+等）或胺具有 显著改变细胞代谢的能力。 商业价值 作为抗球虫药和合成代谢剂，聚醚类抗生素也 强心药 离子载体的治疗应用， 然而，人类强心剂受到其毒性的严重限制 以及阻止有效剂量方案的残留特性。 获得 仍然保留螯合能力的相关化学结构 金属离子/胺可逆，但可以克服一些毒性， 与天然产物相关的代谢稳定性问题可 产生有用治疗剂。 这一努力的目的是 开发可普遍应用于合成的技术， 特征聚醚结构和这些离子载体的设计类似物 通过生物学测试， 活动的参数。 综合方法的初步目标 部分工作是莫能菌素和尼日利亚菌素，然后类似物相关的 这些抗生素将通过该技术制备。

It is the goal of this program to develop efficient, practical (within the context of the complexity of the molecules involved) syntheses of the polyether ionophores. These antibiotics function as agents for ion/amine transport and through their ability to facilitate the transport of biologically relevant ions (Na+, K+, CA2+, etc.) or amines have the capacity to alter significantly cell metabolism. Commercially valuable as coccidiostats and anabolic agents, the polyether antibiotics are also proven cardiotonic agents. Therapeutic utilization of the ionophores as human cardiotonic agents is, however, severely limited by their toxicity and residual character that prevents effective dose regimes. Access to related chemical structures that still retain the ability to chelate metal ions/amines reversibly, but can overcome some of the toxicity and metabolic stability problems associated with the natural products may lead to useful therapeutic agents. It is the purpose of this effort to develop technology that can be generally applied to the synthesis of the characteristic polyether structure and design analogs of these ionophores that through biological testing will help define the requisite structural parameters for activity. Initial targets for the synthetic methodology part of the work are monensin and nigericin and then analogs related to these antibiotics will be prepared by that technology.