CORE--PROGRAM SYNTHETIC CORE

一系列的卤化正构烷烃包含的化合物， 产生麻醉。我们建议合成一些化合物， 位于麻醉和非麻醉区域的边界附近。的 将研究以下化合物的合成，或者通过 现有的方法或通过我们将开发的方法：（1）多氟化的N- 含有氢和/或氯原子或溴原子的烷烃， 末端碳中的一个或两个;（2）二溴全氟环丁烷和 环戊烷;（3）含氢多氟甲基乙基醚 和/或氯原子或溴原子， 碳;（4）多氟化醇。在项目实施期间， 项目我们将准备24化合物根据指令的 把所有的调查员的资料拿出来。我们也要谈谈 样品的再合成，并提供响应任何 根据内核的指示转移焦点 我们参与这项计划项目将增加另一个层面， 该项目我们将贡献氟化学家的观点。 这可能特别有助于小组的讨论 关于这些化合物的物理性质的含义 以及区分麻醉剂和非麻醉剂的因素。 我们的贡献除了提供所需的 化合物，其中一些我们以前做过，在于改进 我们将为已知的合成方法和放大做出贡献， 以中等规模生产化合物所需的技术。

The series of halogenated n-alkanes contains compounds that do and do not produce anesthesia. We propose to synthesize a number of compounds that lie near the border of the anesthetic and nonanesthetic domains. The synthesis of the following compounds will be investigated, either by existing methods or by methods we will develop: (1) polyfluorinated n- alkanes containing hydrogen and/or chlorine atoms, or bromine atoms at one or both of the terminal carbons; (2) dibromoperfluorocyclobutane and cyclopentane; (3) polyfluorinated methyl ethyl ethers containing hydrogen and/or chlorine atoms, or bromine atoms on one or both of the terminal carbons; (4) polyfluorinated alcohols. Over the period of the program project we will prepare 24 compounds according to the directives of the Core and supply these of all the investigators. We will also address resynthesis of samples and provide the flexibility to respond to any shifts in focus as dictated by the Core. Our participation in this Program Project will add another dimension to the project. We will contribute the viewpoint of the fluorine chemist. This might be particularly helpful in the discussions of the group concerning the implications of the physical properties of these compounds and the factors that distinguish anesthetic from nonanesthetic compounds. The significance of our contribution apart from providing the needed compounds, some of which we have made previously, lie in the improvements we will contribute to the known methods of synthesis and to the scale-up technology required to produce the compounds on a medium scale.