Silver Antimicrobial Surface for Improved Performance of Complex Orthopaedic Implant Technologies

该项目将开发和评估一种新型的银基抗菌表面处理方法，用于复杂的骨科设备材料。该项目将建立在埃森哲医疗之前成功商业化的专有Agluna®银离子抗菌技术的基础上，该技术用于传统钛骨科设备表面。目前的项目是由最近的市场趋势推动的，趋向于更复杂的器件材料，例如由增材层制造技术形成的三维多孔结构。随着Agluna®在降低传统器械底物的术后感染发生率和严重程度方面的临床表现，埃森哲医疗正在寻求解决市场对新型银基抗菌表面处理应用于更复杂底物的不断变化的需求。该项目将展示一种可行的表面技术所需的基本安全性和有效性特征，以及所选表面技术的潜力，以适应高度管制的骨科设备行业严格的制造过程控制要求。

The project will develop and evaluate a novel silver based anti-microbial surface treatment for application to complex orthopaedic device materials. The project will build on Accentus Medical's previous successful commercialisation of its proprietary Agluna® silver ion based anti-microbial technology for conventional titanium orthopaedic device surfaces. The current project is driven by recent market trend towards more complex device materials, such as 3-D porous structures formed by e.g. additive layer manufacturing techniques. With the clinical performance demonstrated by Agluna® in reducing the incidence and severity of post-operative infections with conventional device substrates, Accentus Medical is now seeking to address evolving market demand for a novel silver based antimicrobial surface treatment applied to more complex substrates. The project will demonstrate the basic safety and efficacy characteristics required of a viable surface technology, as well as the potential for the selected surface technology to be amenable to rigorous manufacturing process control requirements of the highly regulated orthopaedic device industry.