SUstainable nanoPaRticles Enabled antiMicrobial surfacE coatings (SUPREME)

正在发生的灾难性大流行引起了我们对高流量表面促进有害病原体传播的注意，突出了经济上和环境上可持续的抗菌表面解决方案作为减轻疾病暴发传播的潜在战略的重要性和紧迫性。纳米颗粒（NP）填充涂层具有公认的抗细菌、病毒和真菌的有效性，是开发抗菌表面和最小化病原体表面粘附的有价值的候选者。然而，由于许多技术挑战，包括难以开发具有长期抗菌能力的纳米涂层，在实际条件下的耐久性和安全性保证，其在工业水平上的应用仍然受到限制。SUPREME联盟将开发一个高效、多功能的抗菌纳米涂层平台，以定制的二氧化钛纳米颗粒为基础，该纳米颗粒已在实验室规模上证明了卓越的抗菌能力（TRL3）。两种可持续的途径：1)定制的核/壳和先进的功能纳米粒子和2)混合纤维纳米粒子（使用可持续的生物基纤维素材料和纳米粒子）。考虑到个别应用的具体要求，SUPREME联盟将协调抗菌测试，以确保其对各种病原体的有效性。SUPREME涂料的生产将遵循可持续设计方法，从一开始就考虑毒性和环境影响，以保证整个过程的市场接受度和可持续性，同时对人类健康有强有力的安全保证。这些可持续材料的大规模生产及其根据工业要求的验证将使项目结束时达到TRL6。

The catastrophic ongoing pandemic has attracted our attention towards the spread of harmful pathogens facilitated by high traffic surfaces, highlighting the importance and urgency of an economically and environmentally sustainable solution for antimicrobial surface as a potential strategy to mitigate the spread of disease outbreaks. Nanoparticle (NP) filled coatings, with recognised effectiveness against bacteria, viruses, and fungi, are valuable candidatesfor developing antimicrobialsurface and minimising the surface adhesion of pathogens. However, due to the many technical challenges, including difficulty to develop nanocoatings with a long-term antimicrobial capability, durability under real conditions and safety assurance, their application at industrial level is still limited. The SUPREME consortium will develop a platform of efficient and multifunctional antimicrobial nanocoatings, building upon bespoke TiO2 nanoparticles that have demonstrated an exceptional antimicrobial ability at lab scale (TRL3). Two sustainable routes: 1) customised core/shell and advanced functional nanoparticles and 2) hybrid fibre-nanoparticles (using sustainable bio-based cellulose materials and nanoparticles) will be pursued. Bearing in mind the specific requirements of individual applications, the SUPREME consortium will coordinate the antimicrobial testings to its effectiveness against a wide range of pathogens. The production of the SUPREME coating will follow a sustainable-by-design approach that considers both toxicity and environmental impact from outset to guarantee both market acceptance and sustainability of the overall process whilst having a robust safety assurance in place for human health. The scaling-up production of these sustainable materials and their validation according to the industrial requirements will enable to reach the TRL6 by the end of the project.