Sculpting a masterpiece: synthesis and evolution of minimal yeast genomes

该项目旨在通过工程化具有较少基因的最小酵母基因组来更好地理解基因组的复杂性，因此更容易复制和工程化。酵母是一种模式生物和工业食品，燃料和化学品生产商。该项目旨在增加我们对酵母基因组的基本了解，并开发新的工具来工程化整个基因组。该项目的预期成果包括世界上第一个最小酵母基因组的工程和表征，以及新型工业酵母菌株的开发。这将为基础遗传学和生物化学研究以及酵母在可持续食品、燃料和化学品的生物制造中的工业应用带来重大利益。

This project aims to better understand genome complexity by engineering minimal yeast genomes that have fewer genes, and are therefore easier to characterise and engineer. Yeast is a model organism and industrial food, fuel, and chemical producer. This project expects to increase our basic understanding of yeast genomes, and develop new tools for engineering whole genomes. Expected outcomes of this project include the engineering and characterisation of the world's first minimal yeast genome, and the development of novel industrial yeast strains. This will provide significant benefits for both fundamental genetics and biochemistry research, and the industrial use of yeast for bio-manufacturing of sustainable foods, fuels, and chemicals.