HIP BONE DENSITY IN ELDERLY AFRICAN AMERICAN WOMEN

骨质疏松症和相关骨折在高加索人中更常见 女性多于非裔美国女性。髋部骨折的发生率和 高加索女性的其他非脊椎骨折的比例是 非裔美国女性。然而，髋部骨折的风险增加了 与年龄呈指数关系，不分种族。除了 年龄增长和体重指数低，对危险因素知之甚少 对于非裔美国女性的骨质疏松症来说， 关于老年非裔美国妇女骨矿代谢的数据 总体而言。据推测，这些生活方式和饮食习惯 与骨质疏松症相关的高加索女性也适用于 非裔美国女性。 这项研究的目的是确定骨骼的任何种族差异。 密度、骨矿物质代谢和维生素D受体等位基因 在社区居住的老年妇女(70-80岁)中的频率。一 100名女性(一半是非洲裔美国人，一半是高加索人)将由 测定血清钙、甲状旁腺素代谢物、骨钙素和尿量 羟基脯氨酸。这些研究将使我们能够评估骨转换率。 和矿物质动态平衡。预计在彻底完成后 老年非裔美国人和高加索人的代谢特征 女性，可以得出关于她们臀部预测因素的推论 骨折风险。 研究表明，尽管髋部骨折的发生率是 与高加索女性相比，非裔美国女性的比例有所下降； 那些确实遭受骨折的女性更有可能增加 骨折后的住院死亡率和伤残与 高加索女性。预计得出的数据和推论 这项研究将提高人们对骨质疏松症的认识 它在非裔美国女性中的预防也是在发现 非洲裔美国女性面临骨质疏松症和相关骨折的风险， 这位研究人员计划进行一项干预研究。

Osteoporosis and related fractures occur more frequently among Caucasian women than in African-American women. The incidence of hip fractures and other nonvertebral fractures among Caucasian women is twice that of African-American women. However the risk of hip fracture increases exponentially with age regardless of ethnicity. With the exception of increased age and low body mass index, little is known about risk factors for osteoporosis among African-American women and there is a scarcity of data concerning bone mineral metabolism of elderly African-American women in general. It is presumed that those lifestyle and dietary habits associated with osteoporosis in Caucasian women also apply to African-American women. The purpose of this study is to identify any racial differences in bone density, bone mineral metabolism, and vitamin D receptor allele frequencies among community dwelling elderly women (ages 70-80). One hundred women (half African American, half Caucasian) will be studied by measuring serum calcium, PTH metabolites, osteocalcin, and urinary hydroxyproline. These studies will allow us to assess bone turnover rate and mineral homeostasis. It is anticipated that after thorough characterization of metabolism in elderly African-American and Caucasian women, inferences can be drawn concerning predictors for their hip fracture risk. Studies have shown that although the incidence of hip fracture is decreased among African-American women compared with Caucasian women; those women that do sustain a fracture are more likely to have increased hospital mortality and disability following fracture when compared to Caucasian women. It is anticipated that the data and inferences drawn from this study will lead to an increased awareness of osteoporosis and its prevention among African-American women Also, after identifying African-American women at risk for osteoporosis and related fractures, this investigator plans an intervention study.