OCULAR PROPRIOCEPTION AND EYE/HAND MOTOR CONTROL

本提案的总体目标是调查现有的 视网膜和视网膜外眼信号用于眼睛的控制 运动和眼手协调，以及视觉空间的编码， 在正常和病理情况下。 具体而言，目的是 了解眼睛本体感觉在直接作用中所起的作用- 眼睛运动和视觉引导肢体的直线和自适应控制 动作 将讨论三个具体假设，涉及 眼本体感觉的潜在即时和长期功能：1） 本体感觉有助于眼眶的即时在线编码 眼睛位置2）本体感觉参与适应过程， 确保眼眶位置的准确内部表示; 3） 本体感觉不有助于在线信号中使用 扫视脉冲产生的反馈控制。 这些假设将在恒河猴中进行研究， 比较自我中心和眼中心的空间定位（如在 视觉引导指向）和眼功能（静态眼对准 和扫视度量），在范例中。视觉输入被改变， 其中本体感受传入被修改或消除。 具体地说， 单侧和双侧眼传入阻滞对眼的影响 肢体运动，将在正常猴中进行研究，在被动眼期间 偏差，棱镜适应，参数扫视适应，和 适应单侧眼肌麻痹。 眼球运动将是 用磁探测线圈法测量;指向将被量化 电脑触摸屏。 这项研究将有助于阐明眼神经系统中 本体感觉在眼睛和肢体运动控制，并在视觉空间 perception. 潜在的卫生保健影响包括 理解和治疗各种视觉，眼科， 肌肉运动障碍，如斜视和肢体步态共济失调 与眼肌麻痹有关 该研究计划整合了 运动控制的实验和理论方法培训， 相关疾病的临床经验，以及医学生和 居民教学。

The overall objective of this proposal is to investigate how the available retinal and extraretinal oculomotor signals are used in the control of eye movements and eye-hand coordination, and in the encoding of visual space, in normal and pathological settings. Specifically, the aim is to understand the role played by ocular proprioception in the immediate on- line and adaptive control of eye movements and visually-guided limb movements. Three specific hypotheses will be addressed, concerning potential immediate and long-term functions of ocular proprioception: 1) proprioception contributes to the immediate on-line encoding of orbital eye position 2) proprioception participates in the adaptive processes that ensure an accurate internal representation of orbital eye position; 3) proprioception does not contribute to the on-line signal used in the feedback control of saccadic pulse generation. These hypotheses will be investigated in rhesus monkeys by measuring and comparing egocentric and oculocentric spatial localization (as manifest in visually-guided pointing) and oculomotor function (static ocular alignment and saccade metrics), in paradigms where. visual inputs are altered, and where proprioceptive afference is modified or eliminated. Specifically, the effect of unilateral and bilateral ocular deafferentation on eye and limb movements, will be investigated in normal monkeys, during passive eye deviation, prism adaptation, parametric saccadic adaptation, and adaptation to unilateral ocular muscle palsies. Eye movements will be measured with the magnetic search coil method; pointing will be quantified with a computer touch- screen. The proposed research will help to elucidate the role played by ocular proprioception in eye and limb motor control, and in visuo-spatial perception. Potential health care implications include advances in the understanding and therapy of a variety of visual, oculomotor, and skeletal-motor disorders, such as strabismus and the limb- gait ataxia associated with ocular muscle palsies. The research proposal integrates training in experimental and theoretical approaches to motor control, clinical experience with related disorders, and medical student and resident teaching.