SCHIZOPHRENIC COGNITION--A LONGITUDINAL STUDY

整个研究项目的目标是进一步了解 精神分裂症和其他主要精神病的前瞻性纵向研究 一项对大样本患者进行15年随访的研究 先前在急性期进行了前瞻性研究，并已随访 在十年的时间里四次 以下假设关于 随着时间的推移，精神分裂症的功能和调整， 积极和消极的症状，将得到解决。 假设1：与最近的假设相反，现代精神分裂症患者 仍然有相对较差的结果。 精神分裂症患者很容易受到 持续的紊乱而不仅仅是间歇性的发作。 假设2：精神分裂症患者的精神病随着时间的推移持续存在或复发， 在分裂情感性精神障碍中，但在其他精神障碍中得到缓解。 假设3：负缺陷症状在精神分裂症中持续存在， 确定一个预后不良的精神分裂症患者亚组。 该研究涉及多方面的前瞻性，纵向 调查阳性症状、阴性症状的病程， 随着时间的推移，心理社会功能和调整的主要组成部分， 通过一系列结构化的面试，表现测试， 紊乱测量和行为评级 一个大样本的年轻，非慢性精神分裂症和情感障碍 精神障碍、双相情感障碍、单极精神性抑郁症，以及 对非精神病性精神障碍进行纵向评估。 患者 在急性期、部分恢复期进行了评价， 在产后期间的各个阶段进行随访， 妄想，幻觉，思维混乱，还有阴性症状 他们还被评估为神经症和情感症状， 再住院以及社会和工作适应。 数据用于 评估一些关于精神病的理论，思维障碍，消极的 症状、预后因素，并评估长期临床病程 以及现代精神分裂症的功能和调节水平。

The goal of the overall research project is to further our knowledge about schizophrenia and other major psychoses by a prospective longitudinal investigation involving a 15 year followup of a large sample of patients previously studied prospectively at the acute phase and already followed up four times over a ten year period. The following hypotheses about functioning and adjustment over time in schizophrenia, and about the course of positive and negative symptoms, will be addressed. Hypothesis 1: Contrary to recent hypotheses, modern-day schizophrenics still have relatively poor outcomes. Schizophrenics are vulnerable to a sustained disorder and not just to intermittent episodes. Hypothesis 2: Psychosis persists or recurs over time in schizophrenia, and in schizoaffective disorders, but remits in other psychotic disorders. Hypothesis 3: Negative-deficit symptoms persist in schizophrenia, and they identify a subgroup of poor outcome schizophrenics. The research involves a multi-faceted prospective, longitudinal investigation of the course of positive symptoms, negative symptoms, and major components of psychosocial functioning and adjustment over time, using a battery of structured interviews, performance tests, thought disorder measures, and behavioral ratings. A large sample of young, non-chronic schizophrenic and schizoaffective disorders, bipolar affective disorders, unipolar psychotic depressives, and non-psychotic disorders are being assessed longitudinally. Patients have been evaluated at the acute phase, during partial recovery, and are being followed up at various phases during the posthospital period, for delusions, hallucinations, disordered thinking, and negative symptoms. They also are being assessed for neurotic and affective symptoms, rehospitalization, and social and work adjustment. The data are used to evaluate a number of theories about psychoses, thought disorder, negative symptoms, prognostic factors, and to assess the long-term clinical course and level of functioning and adjustment in modern-day schizophrenia.