ARTERIAL BAROREFLEX CONTROL OF BLOOD PRESSURE EXERCISE

我们实验室对人类的初步研究结果表明，我们的 完全描述“开环”颈动脉压力反射的能力 在较高的颈动脉窦扩张压力下手术(经典 正在重置)。在狗和人类中，主动脉的作用- 压力感受器在运动中调节血压的作用 未知。我们在人类身上记录了不同的不同角色 主动脉和颈动脉压力感受器反射在调节血液中的作用 静息压力以及确定 心肺压力感受器和颈动脉压力感受器。在……里面 此外，这些反射及其相互作用的运作方式也不同。 在不同最大有氧能力水平的个体中 有氧能力(VO-2max)，在男性中可能有不同的操作 与女性相比。因此，我们假设信息 来自颈动脉、主动脉和心肺压力感受器 是全身血压的主要调节器 人体内的动态运动，这种关系是 被个体的有氧健身水平所改变。为了 测试这些假设的可错性，我们将定义 刺激-反应关系和主动脉的相互作用。 稳态运动中的颈动脉和心肺反射 最大有氧能力高和低的个体。许多 实验程序及其修改后的使用情况 都是我们实验室研发出来的。 具体地说，我们将使用不同强度的稳态工作来 建立有规律的血压、颈部压力/吸力 下半身负性扰动颈动脉窦的技术 压力和急性容量扩张改变中心静脉 压力，以及非侵入性的药理和机械手段 隔离主动脉压力感受器反射。拟议的研究将 研究生理机制，并将确定性别 不同之处。这些发现将提供重要的基准 关于各种压力感受器相互作用的信息 人们对运动中血压的调节。

Pilot study findings from humans in our laboratory demonstrate our ability to fully characterize the "open-loop" carotid baroreflexes to operate at a higher carotid sinus distending pressure (classic resetting). in both dogs and humans the role of the aortic- baroreceptors in regulating blood pressure during exercise is unknown. We have documented in humans discrete differential roles of the aortic and carotid baroreceptor reflexes in regulating blood pressure at rest as well as identifying an interaction between cardiopulmonary baroreceptors and carotid baroreflexes. In addition, these reflexes and their interactions operate differently in individuals of differing levels of maximal aerobic capacity aerobic capacity (VO-2max) and may operate differently in men compared to women. Therefore, we hypothesize that information received from the carotid, aortic and cardiopulmonary baroreceptors are the principal modulators of systemic blood pressure during dynamic exercise in the human, and that this relationship is altered by the individual's level of aerobic fitness. In order to test the fallibility of these hypotheses, we will define the stimulus-response relationships and the interactions of the aortic. carotid and cardiopulmonary reflexes during steady-state exercise in individuals with high and low maximal aerobic capacities. Many of the experimental procedures and their modifications for use during exercise have been developed in our laboratory. Specifically, we will use different intensity steady-state work to establish a regulated blood pressure, neck pressure/suction techniques for perturbing the carotid sinus, lower body negative pressure and acute volume expansion to alter central venous pressure, and pharmacologic and mechanical means of non-invasively isolating the aortic baroreceptor reflex. The proposed studies will investigate the physiological mechanisms and will determine gender differences. The findings will provide important baseline information concerning the interactions of the various baroreceptor populations on the regulation of blood pressure during exercise.