Hippocampal regulation of goal-directed decision-making

海马体是大脑的一部分，对学习和记忆至关重要，但人们对它在决策中的作用知之甚少。本申请的目的是提供海马体调节决策的第一个详细的因果证据。这是重要的，因为许多涉及决策缺陷的精神健康障碍和痴呆症的特征是海马功能障碍，但这些因素之间的任何直接联系尚不清楚。目前拨款的结果将提供这种联系的第一个证据，从而更深入地了解这些疾病的神经生理机制，这可能最终导致创造更有益的治疗方法。

The hippocampus is a part of the brain that is central to learning and memory yet little is known about its role in decision-making. It is the aim of this application to provide the first detailed, causal evidence of hippocampal regulation of decision-making. This is significant because many mental health disorders and dementias that involve decision-making deficits are characterised by hippocampal dysfunction, but any direct link between these factors is unknown. The outcomes of the current grant will provide the first evidence of that link, thus providing deeper understanding of the neurophysiological mechanisms of these disorders, which could eventuate in the creation of more beneficial treatments.