Advancing the Chemistry of Metal-organic Frameworks for Biotechnology

这项研究将推进金属有机框架（MOF）生物复合材料新兴领域所需的基础化学科学。酶（生物催化）、蛋白质（基于蛋白质的治疗剂）和基于病毒的疫苗的商业用途的重大挑战是它们对升高的温度和/或非生物介质的不稳定性。MOFs可以封装和保护生物分子，从而克服这一限制。该项目将开发控制这些生物复合材料的形成，稳定性和活性的基本参数，扩大可用于生物保护的MOF材料的范围，并实现工业生物催化和基于蛋白质/病毒的治疗领域的新发展。

This research will advance the fundamental chemical science required for the emerging field of Metal-organic Framework (MOF) biocomposites. A significant challenge to the commercial use of enzymes (biocatalysis), proteins (protein-based therapeutics) and virus-based vaccines is their instability to elevated temperatures and/or non-biological media. MOFs can encapsulate and protect biomolecules, thereby overcoming this limitation. This project will develop fundamental parameters that govern the formation, stability and activity of these biocomposites, expanding the scope of MOF materials available for bioprotection, and enable new developments in the areas of industrial biocatalysis and protein/virus-based therapeutics.