ANTITHROMBOTIC PEPTIDE RELEASE FROM NEW BIOMATERIALS

释放受控剂量的抗血栓形成药物的新型生物材料 将制备的肽注入血液。这些生物材料应该更多 生物相容性，因为它们抑制该区域的凝血， 发生，即在血液聚合物界面。 低温辉光 放电等离子体沉积技术将用于形成非常薄的， 限制肽释放速率的交联涂层 被结合到底层材料中。涂层的变化 条件将允许我们准备释放各种物质的材料， 以所需的速率加入肽。除了抗血栓形成剂， 生物医学用途可以通过这种方式提供，因为这是一个 一种通用的方法，不特定于特定的 肽/聚合物对。

Novel biomaterials that release a controlled dose of an anti-thrombotic peptide into the blood will be prepared. These biomaterials should be more biocompatible because they inhibit coagulation in the region it is likely to occur, namely at the blood polymer interface. A low temperature glow discharge plasma deposition technology will be used to form very thin, crosslinked coatings that limit the rate of release of a peptide incorporated into the underlying material. Variations in the coating conditions will allow us to prepare materials that release various peptides at the desired rate. Besides anti-thrombotics, other peptides of biomedical usefulness could be delivered in this way because this is a somewhat general method that is not specific to the particular peptide/polymer pair.