IMPACT OF SLEEP DISORDERED BREATHING IN OLDER ADULTS

中年人睡眠时呼吸紊乱对健康的影响 在普通人群中，年长的男人和女人身体不好 以及治疗相对较轻程度睡眠的必要性- 呼吸紊乱是未知的。我们假设在临床上 隐性睡眠--呼吸紊乱与血压有关 情绪高涨、与健康相关的生活质量受损和抑郁。 这项研究的目标是在一口井中评估这一假设- 以中老年男性和他们的妻子为特征的队列。这个 这项研究将使用退伍军人标准老龄化研究(NAS)人群，该研究 由大约1700名居住在社区的男子组成，他们回到 每三年进行一次考试。我们将在治疗期间评估呼吸功能 睡在这些男人和他们的妻子中间，使用一种有效的居家方法 睡眠监测。血压、健康相关的生活质量，以及 抑郁评分也将在家里进行评估。潜力 睡眠呼吸障碍与高血压、受损的关系 与健康相关的生活质量和抑郁将被评估， 男性和女性之间的这些关系不同的可能性将是 检查过了。拟议的调查将是第一次人口研究。 研究了睡眠呼吸障碍对这些人健康的影响 结果。这项研究将在临床上建立 中老年男性和老年人的重要睡眠呼吸障碍 并将提供量化数据，作为 选择患者进行筛查，并确定哪些患者可能受益 来自治疗性干预。

The health impact of disordered breathing during sleep among middle-aged and older men and women in the general population has not been well studied, and the need for treating relatively mild degrees of sleep- disordered breathing is unknown. We hypothesize that clinically inapparent sleep-disordered breathing is associated with blood pressure elevation, impairment of health-related quality of life, and depression. The goal of this study is to evaluate this hypothesis in a well- characterized cohort of middle-aged and older men and their wives. The study will use the VA Normative Aging Study (NAS) population, which consists of approximately 1,700 community-dwelling-men who return for examination every three years. We will assess respiratory function during sleep among these men and their wives using a validated method for home sleep monitoring. Blood pressure, health-related quality of life, and depression score will also be assessed in the home. The potential associations of sleep-disordered breathing with hypertension, impaired health-related quality of life, and depression will be evaluated, and the possibility that these relationships differ between men and women will be examined. The proposed investigation would be the first population study which examines the effect of sleep-disordered breathing on these health outcomes. This study will establish the prevalence of clinically important sleep-disordered breathing among middle-aged and older men and women and will provide quantitative data to serve as the basis for selecting patients for screening and deciding which patients may benefit from therapeutic intervention.