UHC/CWRU ALZHEIMERS DISEASE RESEARCH CENTER

拟议中的阿尔茨海默病研究中心（ADRC）将 以现有的个人专门知识和机构承诺为基础 阿尔茨海默病（AD）的研究、临床护理 患者，以及有关知识的传播 毁灭性的混乱 克利夫兰大学医院（UHC） 凯斯西储大学（CWRU）支持阿尔茨海默病中心 负责协调研究、临床护理和教育项目 在AD中。 我们建议的发展检讨委员会将研究 AD中发生的异常从分子生物学到 日常生活活动。 重点将放在 理解不同层次之间的相互关系 科学探究，即信使RNA的变化如何与 细胞功能障碍;细胞功能障碍如何与认知 以及认知障碍如何转化为功能障碍 残疾？ 拟议的ADRC将围绕五个核心进行组织： 1)管理，2）临床（包括患者登记和 数据管理和分析部分），3）研究培训和 信息传输核心（教育核心），4）成像核心，以及 5)神经病理学核心。 三个研究项目将被添加到 现有的研究计划：1）脑血管 衰老和AD（Harik/Kalaria），2）AD中淀粉样蛋白的表征 （Younkin），3）AD中的功能性沟通衰退（Ripich）。 在 此外，我们还提出了几个试点研究项目， 建立在我们现有的试点研究项目上。 第一年拟议的研究包括：免疫染色指纹 神经组织（Caplan），PHF结合蛋白（佩里），和 社会期望的反应倾向和照顾者负担（史密斯）。 第二年的建议包括：医生的态度和做法 对AD患者（Kahana），AD患者的ADL技能和认知状况 （马丁），高级视觉功能在AD（门德斯），和黑色和 老年痴呆症的白色照顾者（Wykle/Segall）。 拟议中的ADRC将允许一个已经有凝聚力的，全国性的 公认的调查小组继续作出重大 对理解这种疾病的贡献， 了解到改善临床护理，并教育外行 团体、专业人士和政策制定者-包括当地和 在全国范围内，关于这种毁灭性的疾病。

The proposed Alzheimer's Disease Research center (ADRC) will be built on existing individual expertise and institutional commitment to the study of Alzheimer's disease (AD), clinical care of patients, and the dissemination of knowledge concerning this devastating disorder. University Hospitals of Cleveland (UHC) and Case Western Reserve University (CWRU) support an Alzheimer Center that coordinates research, clinical care, and educational programs in AD. Our proposed ADRC will examine the functional importance abnormalities occurring in AD ranging from molecular biology to activities of daily living. Emphasis will be placed on understanding inter-relationships between different levels of scientific inquiry, i.e. how do changes in messenger RNA relate to cell dysfunction; how does cell dysfunction relate to cognitive impairment; and how does cognitive impairment convert to functional disability? The proposed ADRC will be organized around five cores: 1) Administrative, 2) Clinical (including a patient registry and a data management and analysis component), 3) Research Training and Information Transfer Core (Education Core), 4) Imaging Core, and 5) Neuropathology Core. Three research projects will be added to the already existing research program: 1) Vessels of the Brain Aging and AD (Harik/Kalaria), 2) Characterization of Amyloid in AD (Younkin), 3) Functional Communication Decline in AD (Ripich). In addition, we propose several pilot research projects which will be built on our already existing pilot grant research program. Studies proposed for year one include: Immunostain Fingerprints of the Neural Tissue (Caplan), PHF Binding Proteins (Perry), and Socially Desirable Response Tendency and Caregiver Burden (Smyth). Second year proposal include: Physicians' Attitudes and Practices toward AD Patients (Kahana), ADL skills and Cognitive Status in AD (Martin), Higher Visual Functions in AD (Mendez), and Black and White Caregivers of Elders with Dementia (Wykle/Segall). The proposed ADRC will permit an already cohesive, nationally recognized group of investigators to continue making major contributions to understanding this disorder, converting this understanding into improved clinical care, and educating lay groups, professionals, and policy makers--both locally and nationally--concerning this devastating disease.