PHYSIOLOGICAL RESPONSES TO TONES IN ACUTE PTSD

对创伤事件的生理反应 以及随后的创伤后应激障碍（PTSD） 仍然模糊不清，未被调查 该项目将试图澄清 通过扩展PI和同事以前的工作， 在慢性创伤后应激障碍患者和急性创伤受试者中进行。 这 以前的工作已经证明了存在升高的， 对响亮音调的习惯性生理反应 慢性PTSD受试者的刺激试验数据来自17个急性 根据本文提出的方法研究的创伤受害者是 非常有希望证实的中心假设的 提出的工作，存在大，不适应自主和 在创伤事件后不久， 预测几个月后PTSD的结果 受试者候选人将从患者人群中招募 在以色列大学医院急诊室， 经历符合DSM-III-R“A”的心理创伤事件 创伤后应激障碍标准。 在指数发布后一周的初步评估中， 创伤性事件，受试者的眼轮匝肌肌电图（EMG）， 皮肤电导和心率对一系列响亮音调的反应 介绍将被衡量。在随后进行的评估中， 在指标事件发生后6个月，将对受试者进行评估 创伤后应激障碍和其他精神障碍的存在， 临床医生管理的PTSD量表（CAPS）和DSM结构化访谈- III-R（SCID）。 将重复音调程序，受试者还将 使用脚本进行进一步的心理生理PTSD评估- 图像驱动程序。 一些PTSD相关的和其他心理测量 也将采取措施。 声调呈现的生理反应之间的关系 以及1个月和6个月时的PTSD结果 评估将通过逻辑回归进行评价。 一些 其他预测变量和潜在的混杂变量， 为计算调整后的 创伤后应激障碍的优势比。

The relationship between the physiological reaction to a traumatic event and the subsequent development of post-traumatic stress disorder (PTSD) remains obscure and uninvestigated. This project will attempt to clarify this relationship by extending previous work of the PI's and colleagues' performed in chronic PTSD patients to acutely traumatized subjects. This previous work has demonstrated the presence of elevated, poorly habituating physiological responses to the presentation of loud tone stimuli in subjects with chronic PTSD Pilot data from seventeen acute trauma victims studied according to the methodology proposed herein are highly promising for confirmation of the central hypothesis of the proposed work that the presence of large, poorly habituating autonomic and eyeblink responses to loud tones shortly after a traumatic event will predict the PTSD outcome months later. Subject candidates will be recruited from the population of patients presenting to an Israeli University Hospital Emergency Room who have just experienced psychologically traumatic events that meet the DSM-III-R "A" PTSD criterion. At an initial assessment one week following the index traumatic event, the subject's orbicularis oculi electromyogram (EMG), skin conductance, and heart rate responses to a series of loud tone presentations will be measured. At subsequent assessments performed one and six months following the index event, the subject will be evaluated for the presence of PTSD and other mental disorders by means of the Clinician-Administered PTSD Scale (CAPS) and Structured Interview for DSM- III-R (SCID). The tone procedure will be repeated, and subjects will also undergo a further psychophysiological PTSD assessment using a script- driven imagery procedure. A number of PTSD-related and other psychometric measures will also be obtained. The relationship between physiological responses to the tone presentations at the one-week assessment and the PTSD outcome at the one- and six-month assessments will be evaluated by means of logistic regression. A number of other predictor variables, and potentially confounding variables, will be entered into the analysis for the purpose of calculating the adjusted odds ratio for PTSD.