FUNCTIONAL ORGANIZATION OF CEREBELLAR OUTPUT

描述（研究者摘要）：我们的长期目标是 了解小脑在控制到达 抓住一个物体。 “伸手去抓”是一个基本的动作， 日常活动和生产的协调“伸手抓”是 高度依赖于小脑功能。 分析小脑 参与“伸手去抓”将导致更好的 了解整个运动系统的组织，并可能 为假肢装置的设计提供了有价值的指导， 以补偿受损的运动控制。 我们已经发现小脑回路专门用于 控制一个“伸手去抓”。 前肢的简单动作 不激活中间小脑环路，但协调 达到和抓住的行动elevantly高利率的神经 放电我们还发现小脑的某些区域 专门用于控制“到达”的特定组件， 把握”。中间小脑只参与控制 抓取部件而不是传送部件 运动 这一建议的总体目标有两个：一是 定义抓取组件中包含的移动 由中间小脑控制，另一个是确定 如果小脑的内侧核控制着 成分 通过确定排放是否取决于 手的运动类型和/或伴随的上臂 支持运动，我们将学习，如果中间小脑 仅控制手部运动或整个肢体的运动， 伴随着特定的手部动作。 一系列的追踪和接触 还将对从内侧记录的装置进行抓握测试 内侧核的决定核参与控制 运输部分。 此外，我们将使用可逆 特定核区域的失活，以观察是否导致 行为缺陷符合我们从 录音实验。

DESCRIPTION (Investigator's Abstract): Our long-range goal is to understand the role of the cerebellum in the control of reaching to grasp an object. The "reach to grasp" is a basic movement used in daily activities, and production of a coordinated "reach to grasp" is highly dependent upon cerebellar function. Analyzing cerebellar participation in the "reach to grasp" will lead to a much better understanding of the organization of the entire motor system and may provide valuable guidance to the design of prosthetic devices attempting to compensate for impaired motor control. We have discovered that cerebellar circuitry is specialized for the control of a "reach to grasp". Simple movements of the forelimb do not activate circuity of intermediate cerebellum, but the coordinated action of reaching and grasping elicits high rates of neural discharge. We have also discovered that regions of the cerebellum are specialized for the control of specific components of the "reach to grasp". Intermediate cerebellum only participates in the control of the grasping component and not the transport component of the movement. There are two overall aims of this proposal: one is to define the movements that are included in the grasp component controlled by intermediate cerebellum, and the other is to determine if the medial nucleus of the cerebellum controls the transport component. By determining whether or not discharge is dependent upon the type of hand movement and/or the accompanying upper arm supporting movements, we will learn if intermediate cerebellum controls only hand movement or movements of the entire limb that accompany specific hand movements. A series of tracking and reaching to grasp test will also be performed on units recorded from medial nucleus to determine of medial nucleus is involved in the control of the transport component. Additionally, we will use reversible inactivation of specific nuclear regions to see if resulting behavioral deficits match the conclusion that we have reached from the recording experiments.